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Synergistic antioxidant and anti-inflammatory action of N-acetylcysteine in portal hypertensive gastropathy in rats.
Licks, Francielli; Minuzzo Hartmann, Renata; Schemitt, Elizângela; Raskopf Colares, Josieli; Marques, Camila; Fillmann, Henrique; Possa Marroni, Norma.
Afiliação
  • Licks F; Program in Biological Sciences: Physiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Minuzzo Hartmann R; Program in Medicine: Medical Sciences, UFRGS; Porto Alegre, RS, Brazil.
  • Schemitt E; Program in Medicine: Medical Sciences, UFRGS; Porto Alegre, RS, Brazil.
  • Raskopf Colares J; Program in BioHealth, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Marques C; Health Science Education Program, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil.
  • Fillmann H; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Possa Marroni N; Program in Biological Sciences: Physiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Hepatol Forum ; 3(2): 51-56, 2022 May.
Article em En | MEDLINE | ID: mdl-35783478
Background and Aim: Portal hypertension (PH) is a syndrome associated with cirrhosis and characterized by a progressive increase in portal pressure, with consequent compensatory vascular dilation. Gastric vascular changes associated with oxidative and nitrosative stress characterize the clinical presentation of portal hypertensive gastropathy (PHG). In addition, the inflammatory process is considered an aggravating factor for severity by contributing to gastric tissue injury. The aim of this study was to investigate the synergistic anti-inflammatory and antioxidant action of N-acetylcysteine (NAC) in the stomach of rats with PH. Materials and Methods: Eighteen Wistar male rats were used in this experimental protocol and were divided into three groups with six in each group: sham-operated (SO), partial portal vein ligation (PPVL), and PPVL + NAC. Treatment with NAC at a dose of 10 mg/kg (i.p.) was initiated on day 8 after surgery and continued for 7 days. We evaluated the expression of iNOS, NQO-1, HSP-90, and SOD by Western blot, as well as nuclear factor-kappa B (NF-κB) and tumor necrosis factor (TNF)-α staining by immunohistochemistry, in the rat stomach. Results: The PPVL group exhibited increased expression of HSP-90, iNOS, SOD, and NQO-1 when compared with controls. NAC reduced the expression of all studied proteins. Similarly, NF-κB and TNF-α staining was increased in PPVL animals versus controls and reduced in PPVL + NAC versus PPVL animals, respectively. Conclusion: These results suggest the effectiveness of NAC as a dual anti-inflammatory and antioxidant in animals with experimental PHG induced by partial ligation of the portal vein.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Hepatol Forum Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Turquia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Revista: Hepatol Forum Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Turquia