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Dysbiosis and Predicted Functions of the Dental Biofilm of Dairy Goats with Periodontitis.
Borsanelli, Ana Carolina; Athayde, Flávia R F; Saraiva, Júlia R; Riggio, Marcello P; Dutra, Iveraldo S.
Afiliação
  • Borsanelli AC; Department of Veterinary Medicine, School of Veterinary Medicine and Animal Science, Universidade Federal de Goiás (UFG), Goiania, Goias, Brazil. anaborsanelli@ufg.br.
  • Athayde FRF; Department of Production and Animal Health, School of Veterinary Medicine, São Paulo State University (Unesp), Araçatuba Campus, Sao Paulo, Brazil.
  • Saraiva JR; Postgraduate Program in Veterinary Medicine, São Paulo State University (Unesp), Jaboticabal Campus, Sao Paulo, Brazil.
  • Riggio MP; School of Medicine Dentistry and Nursing, University of Glasgow, Glasgow, UK.
  • Dutra IS; Department of Production and Animal Health, School of Veterinary Medicine, São Paulo State University (Unesp), Araçatuba Campus, Sao Paulo, Brazil.
Microb Ecol ; 86(1): 687-698, 2023 Jul.
Article em En | MEDLINE | ID: mdl-35780192
Periodontitis is a polymicrobial biofilm-induced inflammatory disease associated with a dysbiotic microbial community and severely affects the health and welfare of animals. However, little is known regarding the dental microbiota associated with this disease in goats. In this study, we used high-throughput sequencing, network analysis, and predicted functions to investigate the microbiota of clinically healthy goats and those with periodontitis and identify possible pathogens and proteins associated with the disease. Dental microbiomes of goats with periodontitis were richer, and network analyses showed that the number of negative interactions was higher in the networks of animals with periodontitis. Based on the interrelationships, Porphyromonas, Fusobacterium, and Prevotella were suggested to play an important role in the dental microbiota associated with goat periodontitis. Protein families linked to translation, cytoplasmatic translation, and rRNA processing were more abundant in the dental microbiota of goats with periodontitis. In conclusion, the dental biofilm microbiota associated with goat periodontitis seems to be dysbiotic and has significant antagonistic interactions, which discriminate healthy animals from diseased animals and highlight the importance of key bacteria. Thus, these novel findings contribute to the evolution of knowledge regarding the etiopathogenesis of goat periodontitis and possibly to the development of periodontitis control measures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Microbiota Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Ecol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Microbiota Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Ecol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos