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Invasive Pneumococcal Disease Characterization in Adults and Subgroups aged < 60 years and ≥ 60 years in Bogota, Colombia.
Castro, Aura Lucia Leal; Camacho-Moreno, Germán; Montañez-Ayala, Anita; Varón-Vega, Fabio; Alvarez-Rodríguez, José Camilo; Valderrama-Beltrán, Sandra; Ariza, Beatriz Elena; Pancha, Oscar; Santana, Ana Yadira; Flórez, Nella Sánchez; Reyes, Patricia; Ruiz, Jaime; Beltran, Claudia; Prieto, Emilia; Rojas, Monica; Urrego-Reyes, Juan; Parellada, Cintia Irene.
Afiliação
  • Castro ALL; Grupo para el control de la resistencia bacteriana en Bogotá, GREBO, Bogotá, Colombia. Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, Departamento de microbiología Oficina 304A, zip code 111321, Bogotá, Colombia.
  • Camacho-Moreno G; Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, zip code 111321, Bogotá, Colombia.
  • Montañez-Ayala A; Asociación Colombiana de Infectología - Capítulo Central, Carrera 15 # 118-03 Of. 503, Edificio Gallerie, zip code 110111, Bogotá, Colombia.
  • Varón-Vega F; Grupo para el control de la resistencia bacteriana en Bogotá, GREBO, Bogotá, Colombia. Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, Departamento de microbiología Oficina 304A, zip code 111321, Bogotá, Colombia.
  • Alvarez-Rodríguez JC; Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, zip code 111321, Bogotá, Colombia.
  • Valderrama-Beltrán S; Asociación Colombiana de Infectología - Capítulo Central, Carrera 15 # 118-03 Of. 503, Edificio Gallerie, zip code 110111, Bogotá, Colombia.
  • Ariza BE; Fundación HOMI Hospital de la Misericordia, Av. Caracas # 1-65, zip code 111411, Bogotá, Colombia.
  • Pancha O; Fundación Hospital Infantil Universitario de San José, Carrera 52 # 67a - 71, zip code 111221, Bogotá, Colombia.
  • Santana AY; Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, zip code 111321, Bogotá, Colombia.
  • Flórez NS; Asociación Colombiana de Infectología - Capítulo Central, Carrera 15 # 118-03 Of. 503, Edificio Gallerie, zip code 110111, Bogotá, Colombia.
  • Reyes P; Fundación Neumológica Colombiana- Fundación Cardioinfantil - Universidad de Navarra, Carrera 13b #161-85, zip code 110131, Bogotá, Colombia.
  • Ruiz J; Universidad Nacional de Colombia, Facultad de Medicina, Carrera 30 # 45 - 03, Edificio 410, zip code 111321, Bogotá, Colombia.
  • Beltran C; Hospital Universitario Clínica San Rafael, Calle 8 # 17-45, zip code 111411, Bogotá, Colombia.
  • Prieto E; Hospital Universitario San Ignacio, Carrera 7 # 40-62, zip code 11023, Bogotá, Colombia.
  • Rojas M; Pontificia Universidad Javeriana, Carrera 7 # 40-62, zip code 110231, Bogotá, Colombia.
  • Urrego-Reyes J; Hospital Universitario San Ignacio, Carrera 7 # 40-62, zip code 11023, Bogotá, Colombia.
  • Parellada CI; Unidad de Servicios de Salud Santa Clara, Subred Centro Oriente, Carrera 14b # 1- 45 sur, zip code 111511, Bogotá, Colombia.
IJID Reg ; 3: 293-299, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35774639
Background: There is scarce information on the burden of invasive pneumococcal disease (IPD) among adults in low- and middle-income countries. This study aimed to describe the clinical outcomes and microbiological characteristics associated with IPD in adults and subgroups aged 18-59 years and ≥60 years in Colombia. Methods: A retrospective chart review study was conducted in five institutions of Bogotá from January 2011 to December 2017. Analyses were carried out for overall population and stratified by age group (18-59; ≥ 60 years). Results: There were 169 IPD cases; median age was 58 years, 51.5% were male, and 80.5% had at least one comorbidity. Bacteremic pneumonia was the most common presentation (63.9%). The median length of hospital stay was 12 days with high healthcare resource utilization (HCRU): 58.6% required ICU and 53.3% inotropic support. Overall case-fatality rate (CFR) was 41.4%. Clinical outcomes were worse in patients ≥60 years old with significantly higher CFR and HCRU (ICU admission, mechanical ventilation, and inotropic support) compared to those aged 18-59 years. The most frequent serotypes were 3, 6 A/C, 14, and 19A. The sensitivity to penicillin in meningitis and non-meningitis isolates were 75% and 89.1% respectively. Conclusions: IPD was associated with a substantial burden in adults and worse clinical outcomes and HCRU in older adults in Colombia. Surveillance data combined with clinical outcomes have the potential to inform age-based pneumococcal vaccination policies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Colombia Idioma: En Revista: IJID Reg Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Colombia Idioma: En Revista: IJID Reg Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido