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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).
Arreola, Jorge; Pérez-Cornejo, Patricia; Segura-Covarrubias, Guadalupe; Corral-Fernández, Nancy; León-Aparicio, Daniel; Guzmán-Hernández, María Luisa.
Afiliação
  • Arreola J; Physics Institute, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. arreola@ifisica.uaslp.mx.
  • Pérez-Cornejo P; Department of Physiology and Biophysics, School of Medicine of Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
  • Segura-Covarrubias G; Physics Institute, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
  • Corral-Fernández N; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
  • León-Aparicio D; Department of Physiology and Biophysics, School of Medicine of Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
  • Guzmán-Hernández ML; Physics Institute, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Handb Exp Pharmacol ; 2022 Jun 30.
Article em En | MEDLINE | ID: mdl-35768554
Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux that controls different physiological functions ranging from muscle contraction, fluid and hormone secretion, gastrointestinal motility, and electrical excitability. Overexpression of ANO1 is associated with pathological conditions such as hypertension and cancer. The molecular cloning of ANO1 has led to a surge in structural, functional, and physiological studies of the channel in several tissues. ANO1 is a homodimer channel harboring two pores - one in each monomer - that work independently. Each pore is activated by voltage-dependent binding of two intracellular calcium ions to a high-affinity-binding site. In addition, the binding of phosphatidylinositol 4,5-bisphosphate to sites scattered throughout the cytosolic side of the protein aids the calcium activation process. Furthermore, many pharmacological studies have established ANO1 as a target of promising compounds that could treat several illnesses. This chapter describes our current understanding of the physiological roles of ANO1 and its regulation under physiological conditions as well as new pharmacological compounds with potential therapeutic applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Handb Exp Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Handb Exp Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha