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Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine.
Malagrino, Thiago R S; Godoy, Anna P; Barbosa, Juliano M; Lima, Abner G T; Sousa, Nei C O; Pedrotti, Jairo J; Garcia, Pamela S; Paniago, Roberto M; Andrade, Lídia M; Domingues, Sergio H; Silva, Wellington M; Ribeiro, Hélio; Taha-Tijerina, Jaime.
Afiliação
  • Malagrino TRS; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Godoy AP; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Barbosa JM; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Lima AGT; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Sousa NCO; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Pedrotti JJ; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Garcia PS; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Paniago RM; Departamento de Física, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil.
  • Andrade LM; Departamento de Física, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil.
  • Domingues SH; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Silva WM; MackGraphe, Mackenzie Institute for Advanced Research in Graphene and Nanotechnologies, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
  • Ribeiro H; Departamento de Química, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil.
  • Taha-Tijerina J; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.
Nanomaterials (Basel) ; 12(12)2022 Jun 15.
Article em En | MEDLINE | ID: mdl-35745394
In this work, flower-like molybdenum disulfide (MoS2) microspheres were produced with polyethylene glycol (PEG) to form MoS2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS2-PEG and MoS2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nanomaterials (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça