Your browser doesn't support javascript.
loading
Hair cortisol in polycystic ovary syndrome.
Gonzalez, D; Maidana, P; Ibar, C; Jamardo, J; Jacobsen, D; Fritzler, A; Fortuna, F; Fernandez, G; Lamas-Majek, E; Mallea-Gil, S; Ballarino, C; Onetto, C; Lopez, M; Mesch, Viviana; Fabre, B.
Afiliação
  • Gonzalez D; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Maidana P; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Ibar C; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Jamardo J; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Jacobsen D; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Fritzler A; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Fortuna F; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
  • Fernandez G; División Ginecología, Hospital de Clínicas "José de San Martín", Universidad de Buenos Aires, 2351 (1120), Córdoba, Buenos Aires, Argentina.
  • Lamas-Majek E; División Ginecología, Hospital de Clínicas "José de San Martín", Universidad de Buenos Aires, 2351 (1120), Córdoba, Buenos Aires, Argentina.
  • Mallea-Gil S; Servicio de Endocrinología, Hospital Militar Central, Luis María Campos, 726 (1426), Buenos Aires, Argentina.
  • Ballarino C; Servicio de Endocrinología, Hospital Militar Central, Luis María Campos, 726 (1426), Buenos Aires, Argentina.
  • Onetto C; División Ginecología, Hospital de Clínicas "José de San Martín", Universidad de Buenos Aires, 2351 (1120), Córdoba, Buenos Aires, Argentina.
  • Lopez M; División Ginecología, Hospital de Clínicas "José de San Martín", Universidad de Buenos Aires, 2351 (1120), Córdoba, Buenos Aires, Argentina.
  • Mesch V; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina. vmesch@ffyb.uba.ar.
  • Fabre B; Departamento de Bioquímica Clínica-Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 956 (1113), Junín, Buenos Aires, Argentina.
Sci Rep ; 12(1): 10309, 2022 06 20.
Article em En | MEDLINE | ID: mdl-35725989
The aim of the study was to evaluate adrenal axis hyperactivation measuring hair cortisol levels, and its influence on the relationship among metabolic parameters, inflammation markers and androgens in adult women with PCOS. 44 women (18-34 years) with PCOS diagnosis and a control group of 49 healthy women (19-35 years) were included. In both gropus body mass index (BMI) was calculated and waist circumference (WC) was measured. Hair cortisol, total serum testosterone (TT), serum cortisol, 25 OH vitamin D (25OHD), insulin, high sensitivity C-reactive protein (hsCRP), triglycerides (TG), HDL cholesterol (HDL), glucose and leptin were measured. Bioavailable testosterone (bioT) was calculated. Hair cortisol concentration was higher and significantly different in PCOS patients compared to the control group (130 vs 63 pg/mg of hair, p < 0.001). Subsequently, patients with PCOS were divided into two groups according to hair cortisol levels: group 1 with normal hair cortisol concentration and group 2 with levels above the upper limit of the reference values (128 pg/mg of hair). In group 2, TT significantly correlated with 25OHD, hsCRP, TG/HDL index, BMI, WC, insulin and HOMA (p < 0.05); bioT correlated with hsCRP and leptin (p < 0.05). Finally, 25OHD was inversely correlated with leptin and with TG/HDL index (p < 0.05). High hair cortisol concentration in patients with PCOS confirmed hyperactivation of the HPA axis. The associations observed were only found in patients with PCOS with high hair cortisol levels (> 128 pg/mg of hair), showing a possible effect of HPA axis in these associations.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Hidrocortisona / Cabelo Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Hidrocortisona / Cabelo Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido