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Local tumour nanoparticle thermal therapy: A promising immunomodulatory treatment for canine cancer.
Castelló, Carla Martí; de Carvalho, Mara Taís; Bakuzis, Andris Figueiroa; Fonseca, Simone Gonçalves; Miguel, Marina Pacheco.
Afiliação
  • Castelló CM; Programa de pós-graduação em Ciência Animal, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Brazil.
  • de Carvalho MT; Programa de pós-graduação em Ciência Animal, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Brazil.
  • Bakuzis AF; Instituto de Física and CNanoMed, Universidade Federal de Goiás, Goiânia, Brazil.
  • Fonseca SG; Setor de Imunologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.
  • Miguel MP; Programa de pós-graduação em Ciência Animal, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Brazil.
Vet Comp Oncol ; 20(4): 752-766, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35698822
Distinct thermal therapies have been used for cancer therapy. For hyperthermia (HT) treatment the tumour tissue is heated to temperatures between 39 and 45°C, while during ablation (AB) temperatures above 50°C are achieved. HT is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In contrast, AB is usually used as a single modality for direct tumour cell killing. Both thermal therapies have been shown to result in cytotoxicity as well as immune response stimulation. Immunogenic responses encompass the innate and adaptive immune systems and involve the activation of macrophages, dendritic cells, natural killer cells and T cells. Several heat technologies are used, but great interest arises from nanotechnology-based thermal therapies. Spontaneous tumours in dogs can be a model for cancer immunotherapies with several advantages. In addition, veterinary oncology represents a growing market with an important demand for new therapies. In this review, we will focus on nanoparticle-mediated thermal-induced immunogenic effects, the beneficial potential of integrating thermal nanomedicine with immunotherapies and the results of published works with thermotherapies for cancer using dogs with spontaneous tumours, highlighting the works that evaluated the effect on the immune system in order to show dogs with spontaneous cancer as a good model for evaluated the immunomodulatory effect of nanoparticle-mediated thermal therapies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Nanopartículas / Hipertermia Induzida / Neoplasias Limite: Animals Idioma: En Revista: Vet Comp Oncol Assunto da revista: MEDICINA VETERINARIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Nanopartículas / Hipertermia Induzida / Neoplasias Limite: Animals Idioma: En Revista: Vet Comp Oncol Assunto da revista: MEDICINA VETERINARIA / NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido