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Antigenotoxic Effect of Ascorbic Acid and Resveratrol in Erythrocytes of Ambystoma mexicanum, Oreochromis niloticus and Human Lymphocytes Exposed to Glyphosate.
Alvarez-Moya, Carlos; Sámano-León, Alexis Gerardo; Reynoso-Silva, Mónica; Ramírez-Velasco, Rafael; Ruiz-López, Mario Alberto; Villalobos-Arámbula, Alma Rosa.
Afiliação
  • Alvarez-Moya C; Environmental Mutagenesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
  • Sámano-León AG; Environmental Mutagenesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
  • Reynoso-Silva M; Environmental Mutagenesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
  • Ramírez-Velasco R; Environmental Mutagenesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
  • Ruiz-López MA; Biotechnology Laboratory, Department of Botany and Zoology, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
  • Villalobos-Arámbula AR; Molecular and Functional Genetics and Ecosystems Laboratory of Biomarkers and Molecular Genetics, Cellular and Molecular Departament, University of Guadalajara, Guadalajara 45200, Jalisco, Mexico.
Curr Issues Mol Biol ; 44(5): 2230-2242, 2022 May 17.
Article em En | MEDLINE | ID: mdl-35678680
Glyphosate is a controversial herbicide. Its genotoxicity and presence in various ecosystems have been reported. The use of ascorbic acid and resveratrol could protect different organisms from glyphosate-induced genetic damage. In the present study, specific genetic damage induced by glyphosate was evaluated in erythrocytes of Oreochromis niloticus, Ambystoma mexicanum and human lymphocytes. Simultaneously, the antigenotoxic capacity of various concentrations of ascorbic acid and resveratrol was evaluated by means of pretreatment and simultaneous treatment protocols. The 0.03, 0.05 and 0.07 mM concentrations of glyphosate induced significant genotoxic activity (p < 0.05) in human lymphocytes and in erythrocytes of the species studied, and could cause genomic instability in these populations. The reduction in genetic damage observed in human lymphocytes exposed to high concentrations of glyphosate is only apparent: excessive genetic damage was associated with undetectable excessive tail migration length. A significant (p < 0.05) antigenotoxic effect of ascorbic acid and resveratrol was observed in all concentrations, organisms and protocols used. Both ascorbic acid and resveratrol play an important role in maintaining the integrity of DNA. Ascorbic acid in Oreochromis niloticus, Ambystoma mexicanum reduced glyphosate-induced genetic damage to a basal level. Therefore, our data indicate that these antioxidants could help preserve the integrity of the DNA of organisms exposed to glyphosate. The consumption of antioxidants is a useful tool against the genotoxicity of glyphosate.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline País/Região como assunto: Mexico Idioma: En Revista: Curr Issues Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline País/Região como assunto: Mexico Idioma: En Revista: Curr Issues Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça