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Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats.
de Britto Rosa, Matheus Camargos; Ribeiro, Paula Reis; de Oliveira Silva, Viviam; Selvati-Rezende, Danubia Aparecida de Carvalho; da Silva, Tácio Peres; Souza, Fernanda Rezende; Cardoso, Maria das Graças; Seixas, Josilene Nascimento; Andrade, Eric Francelino; Pardi, Vanessa; Murata, Ramiro Mendonça; Pereira, Luciano José.
Afiliação
  • de Britto Rosa MC; Veterinary Medicine Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • Ribeiro PR; Veterinary Medicine Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • de Oliveira Silva V; Department of Health Sciences, Universidade Federal de Lavras (UFLA), Mailbox 3037, Lavras, Minas Gerais, 37200-900, Brazil.
  • Selvati-Rezende DAC; Chemistry Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • da Silva TP; Agriculture Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • Souza FR; Veterinary Medicine Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • Cardoso MDG; Chemistry Department, Universidade Federal de Lavras, Mail Box 3037, Lavras, Minas Gerais, Brazil.
  • Seixas JN; Department of Health Sciences, Universidade Federal de Lavras (UFLA), Mailbox 3037, Lavras, Minas Gerais, 37200-900, Brazil.
  • Andrade EF; Department of Health Sciences, Universidade Federal de Lavras (UFLA), Mailbox 3037, Lavras, Minas Gerais, 37200-900, Brazil.
  • Pardi V; Agrarian Sciences Institute, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Unaí, Minas Gerais, 38610-000, Brazil.
  • Murata RM; Department of Foundational Sciences, School of Dental Medicine, East Carolina University (ECU), Greenville, NC, 27834, USA.
  • Pereira LJ; Department of Foundational Sciences, School of Dental Medicine, East Carolina University (ECU), Greenville, NC, 27834, USA.
Diabetol Metab Syndr ; 14(1): 80, 2022 Jun 08.
Article em En | MEDLINE | ID: mdl-35676689
BACKGROUND: Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce. OBJECTIVE: To evaluate the effects of CN ingestion in obese rats. DESIGN: Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose-called 2CN. Treatment was maintained for 28 days. RESULTS: The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate. CONCLUSIONS: Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Diabetol Metab Syndr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Diabetol Metab Syndr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido