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Bolus versus continuous insulin infusion in immediate postoperative blood glucose control in liver transplantation: pragmatic clinical trial.
Fragoso, Luciana Vládia Carvalhêdo; Araújo, Márcio Flávio Moura de; Lobo, Lidianne Fernandes da Silva; Schreen, Dirk; Zanetti, Maria Lúcia; Damasceno, Marta Maria Coelho.
Afiliação
  • Fragoso LVC; Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Araújo MFM; Fundação Oswaldo Cruz, Eusébio, CE, Brazil.
  • Lobo LFDS; Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Schreen D; Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Zanetti ML; Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Damasceno MMC; Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Einstein (Sao Paulo) ; 20: eAO6959, 2022.
Article em En | MEDLINE | ID: mdl-35674591
OBJECTIVE: To analyze the effectiveness and safety of two insulin therapy techniques (continuous and intermittent infusion) in the blood glucose control of people who have undergone liver transplantation, in the immediate postoperative period. METHODS: The study was a prospective, open, pragmatic clinical trial with 42 participants, divided into two groups of 21 patients each, in the immediate postoperative period following liver transplantation. Participants in the Experimental Group and Control Group received continuous infusion and bolus insulin, respectively, starting at capillary blood glucose ≥150mg/dL. RESULTS: There were no statistically significant differences in the blood glucose reduction time to reach the target range between the Experimental Group and Control Group in the transplanted patients (p=0.919). No statistically significant differences regarding the presence of low blood glucose (p=0.500) and in the initial blood glucose value (p=0.345) were found. The study identified the final blood glucose value in postoperative intensive care unit lower and statistically significant in the continuous infusion pump group in relation to the Bolus Group (p<0.001). Additionally, the variation of blood glucose reduction was higher and statistically significant in the continuous method group (p<0.05). CONCLUSION: The continuous infusion method was more effective in the blood glucose control of patients in the postoperative period following liver transplantation. BRAZILIAN REGISTRY OF CLINICAL TRIALS: RBR-9Y5tbp.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Insulina Tipo de estudo: Clinical_trials / Observational_studies Limite: Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Insulina Tipo de estudo: Clinical_trials / Observational_studies Limite: Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil