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High doses of graphene quantum dots impacts on microcirculation system: An observational study.
Barros, Aline Oliveira da Silva; Ricci-Junior, Eduardo; Pereira, Jonathas Xavier; Pikula, Konstantin; Golokhvast, Kirill; Manahães, Alex Christian; Souza, Pedro Filho Noronha; Alencar, Luciana Magalhães Rebelo; Bouskela, Eliete; Santos-Oliveira, Ralph.
Afiliação
  • Barros AODS; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil.
  • Ricci-Junior E; Laboratório de Desenvolvimento Galênico, Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (FF/UFRJ), Brazil.
  • Pereira JX; Instituto de Patologia Tropical e Saúde Pública (IPTSP), Universidade Federal de Goiás (UFG), Goiás 74690-900, Brazil.
  • Pikula K; Polytechnical Institute, Far Eastern Federal University, 10 Ajax Bay, Russky Island, 690922 Vladivostok, Russia; Federal Research Center the Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences, 2, Petrovskogo Str., 677000 Yakutsk, Russia.
  • Golokhvast K; Polytechnical Institute, Far Eastern Federal University, 10 Ajax Bay, Russky Island, 690922 Vladivostok, Russia; Federal Research Center the Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences, 2, Petrovskogo Str., 677000 Yakutsk, Russia; Laboratory of Supercritical Flu
  • Manahães AC; Laboratório de Neurofisiologia, Instituto de Biologia Roberto Alcantara Gomes,Universidade Do Estado Do Rio de Janeiro, Rio de Janeiro 20550170, Brazil.
  • Souza PFN; Laboratory of Plant Defense Proteins, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Brazil.
  • Alencar LMR; Federal University of Maranhão, Campus Avançado, Maranhão, Center for Social Sciences, Health and Technology, Maranhão 65900-410, Brazil; Federal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, Maranhão 65080-805, Brazil.
  • Bouskela E; Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular (BioVasc), Rio de Janeiro 20550-013, Brazil.
  • Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil; Rio de Janeiro State University, Laboratory of Nanoradiopharmaceuticals and Radiopharmacy, Rio de Janeiro, Rio de J
Eur J Pharm Biopharm ; 176: 180-187, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35640783
Graphene and its derivatives are in the edge of technology with a wide and diverse range of applications. In the last years, especially graphene quantum dots (GQDs) have had their biomedical application expanded in scope, mainly focused on cancer therapy, drug delivery and imaging. Although many studies have evaluated the application of this nanomaterial in biomedical field, only a few studies aimed to understand their biological impact in human health. In this regard, here we evaluated the impact of high doses of GQDs on the microcirculation of a healthy animal model to better assess risks of its use in humans. Our data show that successive applications of GQDs cause irreversible damage to the microcirculation. After seven days, a complete destruction of the microcirculation has been observed. In addition, GQDs showed substantial activity in human erythrocytes. Our findings suggest that risks associated with the use of GQDs, as well as all graphene derivatives, must be better understood, especially concerning biomedical application. A greater understanding of how GQDs impact body circulation, including the context of environmental and engineered nanosystems, is of paramount importance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pontos Quânticos / Nanoestruturas / Grafite Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pontos Quânticos / Nanoestruturas / Grafite Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda