Your browser doesn't support javascript.
loading
Clinical Effects of the Immunization Protocol Using Loxosceles Venom in Naïve Horses.
Miranda, Ana Luísa Soares de; Antunes, Bruno Cesar; Minozzo, João Carlos; Lima, Sabrina de Almeida; Botelho, Ana Flávia Machado; Campos, Marco Túlio Gomes; Chávez-Olórtegui, Carlos Delfin; Soto-Blanco, Benito.
Afiliação
  • Miranda ALS; Department of Veterinary Clinics and Surgery, Veterinary College, Federal University of Minas Gerais, Belo Horizonte 30123-970, MG, Brazil.
  • Antunes BC; Department of Health of the State of Paraná, Production and Research Center of Immunobiologicals, Piraquara 80230-140, PR, Brazil.
  • Minozzo JC; Department of Health of the State of Paraná, Production and Research Center of Immunobiologicals, Piraquara 80230-140, PR, Brazil.
  • Lima SA; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Botelho AFM; Department of Veterinary Medicine, Veterinary College, Federal University of Goiás, Campus Samambaia, Goiânia 74690-900, GO, Brazil.
  • Campos MTG; Department of Veterinary Clinics and Surgery, Veterinary College, Federal University of Minas Gerais, Belo Horizonte 30123-970, MG, Brazil.
  • Chávez-Olórtegui CD; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Soto-Blanco B; Department of Veterinary Clinics and Surgery, Veterinary College, Federal University of Minas Gerais, Belo Horizonte 30123-970, MG, Brazil.
Toxins (Basel) ; 14(5)2022 05 13.
Article em En | MEDLINE | ID: mdl-35622586
Bites of brown spiders (Loxosceles spp.) are responsible for dermonecrotic lesions and potentially systemic envenoming that can lead to death. The only effective therapy is the use of the antivenom, usually produced in horses. However, little is known about the consequences of the systematic use of the Loxosceles venom and adjuvants and of the bleedings on antivenom-producing horses. Thus, the aim of this study was to evaluate the clinical changes in horses in their first immunization protocol for Loxosceles antivenom production. Eleven healthy horses, never immunized, were evaluated in three different periods: T0 (before immunization); T1 (after their first venom immunization); and T2 (after their first bleeding). Horses were clinically evaluated, sampled for blood, and underwent electrocardiographic (ECG) recordings. Several suppurated subcutaneous abscesses occurred due to the use of Freund's adjuvants and thrombophlebitis due to systematic venipunctures for the bleeding procedures. ECG showed arrhythmias in few horses in T2, such as an increase in T and R waves. In summary, the immunization protocol impacted on horses' health, especially after bleeding for antivenom procurement.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Venenos de Aranha / Aranhas Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Venenos de Aranha / Aranhas Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça