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Pediatric Inflammatory Bowel Disease: A Multicenter Study of Changing Trends in Argentina Over the Past 30 Years.
Arcucci, Maria Soledad; Contreras, Monica Beatriz; Gallo, Julieta; Antoniska, Mariela Andrea; Busoni, Veronica; Tennina, Cecilia; D'Agostino, Daniel; Kakisu, Maria Hisae; Weyersberg, Christian; Orsi, Marina.
Afiliação
  • Arcucci MS; Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Contreras MB; Pediatric Gastroenterology Service, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.
  • Gallo J; Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Antoniska MA; Pediatric Gastroenterology Service, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.
  • Busoni V; Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Tennina C; Pediatric Gastroenterology Service, Hospital de Niños, Dr. Ricardo Gutierrez, Buenos Aires, Argentina.
  • D'Agostino D; Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Kakisu MH; Pediatric Service, Hospital Privado de la Comunidad, Buenos Aires, Argentina.
  • Weyersberg C; Pediatric Gastroenterology Service, Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.
  • Orsi M; Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Pediatr Gastroenterol Hepatol Nutr ; 25(3): 218-227, 2022 May.
Article em En | MEDLINE | ID: mdl-35611373
Purpose: To analyze the characteristics of pediatric inflammatory bowel disease (IBD) over the past three decades in Argentina and determine if there are differences between the first two decades and the past decade. Methods: We conducted a retrospective multicenter analytical study in children with IBD between 0 and 18 years of age diagnosed between 1987 and 2017 in three tertiary health centers in Argentina. The evaluation included clinical characterization, endoscopy, histology, and imaging data together with therapeutic strategies. The patients were divided into two groups: Group 1, diagnosed between 1987 and 2007, and Group 2, diagnosed between 2008 and 2017. Results: Of the 756 patients included, 409 (54%) had ulcerative colitis (UC), 250 (33%) had Crohn's disease (CD), and 97 (13%) had IBD-unclassified (IBD-U). The positive family history was 3.8%, which was more frequent among children under two years of age (6.7%). There were no significant differences in clinical presentation and extraintestinal manifestations between periods, with hepatic manifestations being the most frequent. In the last decade, we found an upward trend in CD, a downward trend in UC/IBD-U, even after adjustment for socioeconomic status, and a decrease of 50% in surgical treatments coinciding with the advent of biological therapy. Conclusion: This is the first multicenter cohort study in a Latin American country to describe clinical, endoscopic, and therapeutic data across the past 30-year period. Although CD was responsible for the overall increase in incidence, UC was still prevalent in this region.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies País/Região como assunto: America do sul / Argentina Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação:
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies País/Região como assunto: America do sul / Argentina Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: