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High anesthetic (isoflurane) indoor pollution is associated with genetic instability, cytotoxicity, and proliferative alterations in professionals working in a veterinary hospital.
Figueiredo, Drielle B S; Aun, Aline G; Souza, Kátina M; Nishimoto, Igor H; Silva, Mariane A P; de Carvalho, Lídia R; Braz, Leandro G; Braz, Mariana G.
Afiliação
  • Figueiredo DBS; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • Aun AG; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • Souza KM; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • Nishimoto IH; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • Silva MAP; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • de Carvalho LR; Institute of Biosciences, São Paulo State University - UNESP, 250, Prof. Dr. Antônio Celso Wagner Zanin, Botucatu, 18618-689, Brazil.
  • Braz LG; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil.
  • Braz MG; GENOTOX Laboratory, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mario Rubens G. Montenegro Av., Botucatu, 18618-687, Brazil. mgbraz@hotmail.com.
Environ Sci Pollut Res Int ; 29(47): 71774-71784, 2022 Oct.
Article em En | MEDLINE | ID: mdl-35606583
This is the first study to monitor anesthetic pollution in veterinary operating rooms (VOR) and assess the toxicological impact of the inhalational anesthetic isoflurane (exposed group) compared to matched volunteers (control group). DNA damage was evaluated in mononuclear cells by the comet assay while genetic instability (including micronucleus-MN), cell proliferation, and cell death markers were assessed by the buccal MN cytome assay. Residual isoflurane concentrations in VOR (air monitoring) lacking the scavenging system were assessed by infrared spectrophotometry; the mean concentration was 11 ppm (≥ 5 times above the international recommended threshold). Comet assay results did not differ between groups; however, both younger exposed professionals (with higher week workload) compared to older individuals exposed for the same period and older professionals with greater time of exposure (years) compared to those in the same age group with fewer years of exposure presented higher DNA damage. The exposed group had a higher frequency of MN, nuclear buds, binucleated cells, karyorrhexis, and karyolysis and a lower frequency of basal cells than the control group. Exposed women were more vulnerable to genetic instability and proliferative index; exposed men presented more cytotoxicity. High WAG exposure has deleterious effects on exposed professionals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exposição Ocupacional / Poluição do Ar em Ambientes Fechados / Anestésicos Inalatórios / Isoflurano Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
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Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exposição Ocupacional / Poluição do Ar em Ambientes Fechados / Anestésicos Inalatórios / Isoflurano Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha