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Effects of medicinal plants and natural compounds in models of prostate cancer related to sex steroids: A systematic review.
Miranda, Rafael Abe da Rocha; Oliveira, Marcela Martins de Paula; Sampaio, Maria Isadora Gabriel; Gomes, João Victor Dutra; Silveira, Damaris; Guerra, Eliete Neves Silva; Lofrano-Porto, Adriana; Meireles, Cinthia Gabriel; Simeoni, Luiz Alberto.
Afiliação
  • Miranda RADR; Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Oliveira MMP; Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Sampaio MIG; Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Gomes JVD; Laboratory of Natural Products, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Silveira D; Laboratory of Natural Products, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Guerra ENS; Laboratory of Oral Histopathology, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Lofrano-Porto A; Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
  • Meireles CG; Gonadal and Adrenal Diseases Clinics, University Hospital of Brasília, University of Brasília, Brasília, Brazil.
  • Simeoni LA; Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
Phytother Res ; 36(8): 3032-3079, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35605997
Prostate cancer remains a health problem for men. Targeting androgen (AR) and estrogen (ER) receptors improves the outcomes of the disease, and many medicinal plants exert their effects by modulating these pathways. Therefore, a systematic review was conducted to identify medicinal plants and their natural compounds that may modulate the AR and/or ER pathways in cell and animal models. A search was conducted across EMBASE, LILACS, PubMed, Scopus, and Web of Science, with grey literature from Google SCHOLAR and ProQuest. Two authors independently selected eligible studies based on their titles and abstracts, and a third author resolved conflicts. Then, data from the full text of eligible studies were extracted and synthesized. In total, 75 studies were included. Results showed the effects of several different medicinal plants and natural compounds in reduction of AR and/or ER transcription and translation and AR secondary effects: cell growth reduction, induction of apoptosis, and cell cycle arrest. In animal models, tumor size reduction, increase in apoptosis, and downregulation of AR expression in tumors were also observed. No single phytochemical group concentrating molecules with anti-AR and/or ER activity was identified. Nevertheless, several phytochemical compounds showed potential for future clinical studies in the management of the disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Neoplasias da Próstata Tipo de estudo: Systematic_reviews Limite: Animals / Humans / Male Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Neoplasias da Próstata Tipo de estudo: Systematic_reviews Limite: Animals / Humans / Male Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido