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Incidence and determinats of augmented renal clearance in traumatic brain injury: A prospective observational study.
Campassi, María Luz; Repetto, Fabio Germán; Banegas Litardo, David María; Castor, Rocío; Gómez, Gisela; Tiseyra, Belén; Flores, Lucas; Ramirez, Irupe; Maspoli, Daniela; Báez, Jimena; Boroni, Ivana; Bertola, Ramiro; Estenssoro, Elisa; Dubin, Arnaldo.
Afiliação
  • Campassi ML; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Repetto FG; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Banegas Litardo DM; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Castor R; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Gómez G; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Tiseyra B; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Flores L; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Ramirez I; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Maspoli D; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Báez J; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Boroni I; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Bertola R; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina.
  • Estenssoro E; Servicio de Terapia Intensiva, Hospital Interzonal de Agudos General San Martin, 1900 La Plata, Buenos Aires, Argentina.
  • Dubin A; Servicio de Terapia Intensiva, Clínica La Pequeña Familia, Ruta 188 y Alberdi, B6000 Junín, Buenos Aires, Argentina; Servicio de Terapia Intensiva, Sanatorio Otamendi, Azcuénaga 870, C1115AAB Ciudad Autónoma de Buenos Aires, Argentina; Cátedras de Farmacología Aplicada y Terapia Intensiva, Facultad
J Crit Care ; 70: 154065, 2022 08.
Article em En | MEDLINE | ID: mdl-35605338
PURPOSE: To characterize the incidence, timing, and predictors of augmented renal clearance (ARC) in patients with traumatic brain injury (TBI). MATERIALS AND METHODS: In 61 patients with TBI, creatinine clearance (CrCl) was prospectively measured from urine samples, over seven days. ARC was defined as a CrCl >130 mL/min/1.73 m2 in at least one day. We compared patients with and without ARC. RESULTS: We performed 295 determinations of CrCl. ARC was present in 82% of the patients and arose in the first 2 days in 86% of them. ARC was more frequent in patients with associated injuries (100 vs. 75%, P = 0.02). There was a trend to a more aggressive resuscitation in patients with ARC but young age was the only independent predictor. Hospital length of stay was higher in ARC (15 [8-25] vs. 6 [3-19] days, P < 0.05). CONCLUSIONS: ARC is very common and has an early appearance in patients with TBI. Young age is its main determinant.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal / Lesões Encefálicas Traumáticas Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Crit Care Assunto da revista: TERAPIA INTENSIVA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Insuficiência Renal / Lesões Encefálicas Traumáticas Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Crit Care Assunto da revista: TERAPIA INTENSIVA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos