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Antimicrobial Action, Genotoxicity, and Morphological Analysis of Three Calcium Silicate-Based Cements.
Abu Hasna, Amjad; Theodoro, Ana Luisa; Pereira, Larissa Marques; Ramos, Lucas de Paula; Campos, Tiago Moreira Bastos; Ala Rachi, Maisour; Al-Nahalwi, Talal; de Oliveira, Luciane Dias; Carvalho, Cláudio Antonio Talge.
Afiliação
  • Abu Hasna A; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
  • Theodoro AL; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
  • Pereira LM; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
  • Ramos LP; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
  • Campos TMB; Physics Department, Aeronautics Technological Institute (ITA), São José dos Campos, São Paulo, Brazil.
  • Ala Rachi M; Department of Operative Dentistry, Syrian Private University (S.P.U), Damascus, Syria.
  • Al-Nahalwi T; Department of Operative Dentistry, Syrian Private University (S.P.U), Damascus, Syria.
  • de Oliveira LD; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
  • Carvalho CAT; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil.
Biomed Res Int ; 2022: 2155226, 2022.
Article em En | MEDLINE | ID: mdl-35592523
This study is aimed at evaluating five mineral oxides (5MO), mineral trioxide aggregate repair high plasticity (MTA HP), and mineral trioxide aggregate (MTA) in relation to the antimicrobial action over Porphyromonas gingivalis, Porphyromonas endodontalis, Parvimonas micra, Fusobacterium nucleatum, and Prevotella intermedia; the genotoxicity over mouse macrophage (RAW 264.7) and osteoblast (Mg-63) cultures; and the morphological analysis using scanning electron microscopy (SEM) analysis (50 k and ×100 k). Sodium hypochlorite (NaOCl), calcium hydroxide, and saline solution were used as control groups in the different analysis. All data were submitted to a normality test and then analyzed with one-way ANOVA, Tukey, and Kruskal-Wallis and Dunn tests, considering α ≤ 0.05 significance level. It was found that over P. gingivalis and P. endodontalis, there was no a significant difference between the calcium silicate-based cements (CSC) and the control group of saline solution, and only 5MO was similar to the NaOCl group. However, over P. micra, all groups were effective and showed a statistically significant difference compared to the saline solution group. Conversely, none of the groups were effective over F. nucleatum and P. intermedia, except of the NaOCl group. There was a significant difference between 5MO and MTA groups in comparison with NaOCl and MTA HP over osteoblasts and macrophages after 24 hours. SEM images showed small irregular particles interspersed with some elongated needle-like particles and small irregular particles with some larger particles as well as elongated particles. It was concluded that 5MO, MTA, and MTA HP have effective antimicrobial action over P. micra. However, only 5MO is effective over P. gingivalis and P. endodontalis. Besides, 5MO and MTA are not genotoxic over mouse macrophage (RAW 264.7) and osteoblast (Mg-63) cultures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Anti-Infecciosos Limite: Animals Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Anti-Infecciosos Limite: Animals Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos