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Incidence of hemoglobinopathies and spatialization of newborns with sickle cell trait in Mato Grosso do Sul, Brazil.
Cândido-Bacani, Priscila de Matos; Grilo, Patrícia Medeiros Silva; Ramos, Vanessa da Silveira; Zanchin, Michelly; Pereira, Indiara Correia; Oliveira, Josaine Sousa Palmieri; Bacani, Vitor Matheus; Belini Junior, Edis.
Afiliação
  • Cândido-Bacani PM; Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
  • Grilo PMS; Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
  • Ramos VDS; Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
  • Zanchin M; Instituto de Pesquisas, Ensino e Diagnósticos, Associação de Pais e Amigos dos Excepcionais, Campo Grande, MS, Brazil.
  • Pereira IC; Instituto de Pesquisas, Ensino e Diagnósticos, Associação de Pais e Amigos dos Excepcionais, Campo Grande, MS, Brazil.
  • Oliveira JSP; Instituto de Pesquisas, Ensino e Diagnósticos, Associação de Pais e Amigos dos Excepcionais, Campo Grande, MS, Brazil.
  • Bacani VM; Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
  • Belini Junior E; Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
Einstein (Sao Paulo) ; 20: eAO6535, 2022.
Article em En | MEDLINE | ID: mdl-35584443
OBJECTIVE: To evaluate the incidence of variant hemoglobins of newborn samples from the Neonatal Screening Center in the state of Mato Grosso do Sul, Brazil, and to analyze the distribution and spatial autocorrelation of newborns with sickle cell trait. METHODS: Samples from 35,858 newborns screened by the Neonatal Screening Center. The samples with inconclusive diagnosis were submitted to electrophoretic, chromatographic, cytological and molecular analyses. The spatial distribution analysis of newborns with sickle cell trait was performed by spatial autocorrelation. RESULTS: A total of 919 newborns showed an abnormal hemoglobin profile; in that, ten genotypes had significant clinical impacts identified. Among the asymptomatic newborns, the sickle cell trait was the most frequent (incidence of 1.885 cases/100 newborns). The highest incidence rates were registered in the municipalities of Terenos, Figueirão, Corguinho and Selvíria. There was positive spatial autocorrelation between the proportion of declared individuals of black race/color and the incidence of newborns with sickle cell trait. CONCLUSION: The early diagnosis by neonatal screening and laboratory tests was very important to identify abnormal hemoglobin profiles and guide the spatial autocorrelation analysis of sickle cell trait newborns in Mato Grosso do Sul, serving as a support to anticipate health measures aimed to discuss efficient therapeutic behaviors and effective planning of municipalities with the greatest need for care, monitoring and orientations for affected families.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traço Falciforme / Hemoglobinas Anormais / Hemoglobinopatias / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traço Falciforme / Hemoglobinas Anormais / Hemoglobinopatias / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil