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Neuroinflammatory Disease following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children.
Aubart, Melodie; Roux, Charles-Joris; Durrleman, Chloé; Gins, Clarisse; Hully, Marie; Kossorotoff, Manoelle; Gitiaux, Cyril; Levy, Raphaël; Moulin, Florence; Debray, Agathe; Belhadjer, Zahra; Georget, Emilie; Kom, Temi; Blanc, Philippe; Wehbi, Samer; Mazeghrane, Mustapha; Tencer, Jeremie; Gajdos, Vincent; Rouget, Sebastien; De Pontual, Loic; Basmaci, Romain; Yacouben, Karima; Angoulvant, Francois; Leruez-Ville, Marianne; Sterlin, Delphine; Rozenberg, Flore; Robert, Matthieu P; Zhang, Shen-Ying; Boddaert, Nathalie; Desguerre, Isabelle.
Afiliação
  • Aubart M; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research U1163, University of Paris-Cité, Imagine Institute, Paris, France. Elect
  • Roux CJ; Pediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Durrleman C; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Gins C; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Hully M; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Kossorotoff M; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Gitiaux C; Pediatric Neurophysiology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France; French Institute of Health and Medical Research U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil, France.
  • Levy R; Pediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Moulin F; Intensive Care Unit, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Debray A; Pediatic Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Belhadjer Z; Pediatric Cardiology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Georget E; Pediatic Department, Villeneuve Saint Georges Hospital, Villeneuve Saint Geroges, France.
  • Kom T; Pediatic Department, Louis Pasteur Hospital, Le Coudray, France.
  • Blanc P; Pediatic Department, Poissy Intercommunal Hospital Center, Poissy, France.
  • Wehbi S; Pediatic Department, Andre Mignot Hospital, Versailles, France.
  • Mazeghrane M; Pediatic Department, Andre Gregoire Hospital, Montreuil, France.
  • Tencer J; Pediatic Department, Delafontaine Hospital, Saint Denis, France.
  • Gajdos V; Pediatic Department, Antoine Béclère Hospital, APHP, Paris-Saclay University, Clamart, France.
  • Rouget S; Pediatic Department, Sud Francilien Hospital, Corbeil-Essone, France.
  • De Pontual L; Pediatric Department, Jean Verdier Hospital, APHP, University of Paris-Cité, Bondy, France.
  • Basmaci R; Pediatric Department, Louis Mourier Hospital, APHP, University of Paris-Cité, Colombes, France.
  • Yacouben K; Pediatric Hematology Department, Robert Debre Hospital, APHP, University of Paris-Cité, Paris, France.
  • Angoulvant F; Pediatric Department, Robert Debre Hospital, APHP, University of Paris-Cité, Paris, France.
  • Leruez-Ville M; Laboratory of Virology, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Sterlin D; Immunology Department, Pitié-Salpétrière Hospital, Sorbonne University, APHP, Paris, France.
  • Rozenberg F; Laboratory of Virology, Cochin Hospital, APHP, University of Paris-Cité, Paris, France.
  • Robert MP; Ophthalmology Department, Necker-Enfants Hospital, APHP, University of Paris-Cité, Paris, France.
  • Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, French Institute of Health and Medical Research U1163, University of Paris-Cité, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New Yo
  • Boddaert N; Pediatric Radiology Department, Necker-Enfats malades Hospital, APHP, University of Paris-Cité, Paris, France.
  • Desguerre I; Pediatric Neurology Department, Necker-Enfants malades Hospital, APHP, University of Paris-Cité, Paris, France.
J Pediatr ; 247: 22-28.e2, 2022 08.
Article em En | MEDLINE | ID: mdl-35577119
OBJECTIVE: To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. STUDY DESIGN: We focused on CNS inflammatory diseases in children referred from 12 hospitals in the Paris area to Necker-Sick Children Reference Centre. RESULTS: We identified 19 children who had a history of SARS-CoV-2 infection and manifest a variety of CNS inflammatory diseases: encephalopathy, cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospinal fluid was abnormal in 58% (11/19) and magnetic resonance imaging was abnormal in 74% (14/19). We identified an autoantibody co-trigger in 4 children (myelin-oligodendrocyte and aquaporin 4 antibodies), representing 21% of the cases. No autoantibody was found in the 6 children whose CNS inflammation was accompanied by a multisystem inflammatory syndrome in children. Overall, 89% of patients (17/19) received anti-inflammatory treatment, primarily high-pulse methylprednisolone. All patients had a complete long-term recovery and, to date, no patient with autoantibodies presented with a relapse. CONCLUSIONS: SARS2-CoV-2 represents a new trigger of postinfectious CNS inflammatory diseases in children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Pediatr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Pediatr Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos