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Molecular signature of immunological mechanism behind impaired endometrial receptivity in polycystic ovarian syndrome.
Amjadi, Fatemehsadat; Zandieh, Zahra; Mehdizadeh, Mehdi; Ajdary, Marziyeh; Aghamajidi, Azin; Raoufi, Ehsan; Aflatoonian, Reza.
Afiliação
  • Amjadi F; Akbarabadi IVF clinic, Akbarabadi Hospital, Iran University of Medical Science, Tehran, Iran.
  • Zandieh Z; Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, Iran.
  • Mehdizadeh M; Akbarabadi IVF clinic, Akbarabadi Hospital, Iran University of Medical Science, Tehran, Iran.
  • Ajdary M; Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, Iran.
  • Aghamajidi A; Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, Iran.
  • Raoufi E; Reproductive Sciences and Technology Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Aflatoonian R; Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Arch Endocrinol Metab ; 2022 May 12.
Article em En | MEDLINE | ID: mdl-35551681
Objective: Despite the treatment of anovulation, infertility is still one of the main complications in PCOS women during reproductive age, which appears to be mainly due to impaired uterine receptivity. This study investigated the transcriptome profiles of endometrium in PCOS patients and healthy fertile individuals as the control group. Methods: Total mRNA was extracted from endometrial tissues of PCOS patients (n = 12) and healthy fertile individuals (n = 10) during the luteal phase. After cDNA synthesis, PCR array was performed using Human Female Infertility RT2 Profiler PCR Array kit (Qiagen, Cat.No: PAHS-164Z) for evaluating expression of 84 genes contributing to the female infertility. Results: PCR Array data analysis identified significantly greater expression of CSF, IL11, IL15, IL1r1, IL1b, TNF, LIF, TNFRSF10B, TGFß, C3, ITGA4 (Cd49d), SPP1, and Calca in PCOS women than in controls (P < 0.05). However, the expression of LIFR, C2, CD55, CFD, CALCA, LAM1, LAMC2, MMP2, MMP7, MMP9, ESR, SELL, ITGB3, and VCAM1 was significantly lower in PCOS group than in controls (P < 0.05). The results revealed dysregulation of immune-inflammatory molecules, complement activation and downregulation of IGF-I as well as adhesion molecules in PCOS group. Conclusion: The findings of this study indicated some potential causes of reduced receptivity of endometrium thus compromising the fertility in PCOS patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil