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Vitamin D Receptor Gene Polymorphisms, ß-cell Function, and Vitamin D Status in Non-obese Mexican Adults.
Piña-Aguero, Mónica Ivette; Maldonado-Hernández, Jorge; Sebastián-Medina, Leticia; Tejero-Barrera, María Elizabeth; Robledo-Pérez, Ricardo Martín; Villalpando-Hernández, Salvador; Ventura-Bravo, Zobeida Analilia; Morales-Ramírez, Laura Katia.
Afiliação
  • Piña-Aguero MI; Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
  • Maldonado-Hernández J; Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address: jormh@yahoo.com.mx.
  • Sebastián-Medina L; Laboratorio de Nutrigenómica y Nutrigenética, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
  • Tejero-Barrera ME; Laboratorio de Nutrigenómica y Nutrigenética, Instituto Nacional de Medicina Genómica, Ciudad de México, México.
  • Robledo-Pérez RM; Laboratorio de Diagnóstico, Universidad Politécnica del Estado de Morelos, Cuernavaca, Morelos, México.
  • Villalpando-Hernández S; Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
  • Ventura-Bravo ZA; Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
  • Morales-Ramírez LK; Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Arch Med Res ; 53(4): 416-422, 2022 06.
Article em En | MEDLINE | ID: mdl-35501225
BACKGROUND: FokI (rs2228570 T>C) and BsmI (rs1544410 A>G) polymorphisms of the vitamin D receptor (VDR) have been associated to abnormal glucose metabolism and could be inversely associated with ß-cell function (BCF) and vitamin D status. There is a lack of information about this topic in the Mexican population. AIM OF THE STUDY: To evaluate the relationship between VDR gene polymorphisms FokI and BsmI with BCF and vitamin D status in a population of non-obese Mexican adults. METHODS: A sample of 192 participants were enrolled during 2016-2018. Blood samples were collected to determine fasting concentrations of glucose, insulin, and vitamin D. Genomic DNA was isolated from leucocytes and the polymorphic variants of FokI and BsmI were analyzed. The Homeostasis Model Assessment Calculator was used to estimate the BCF (HOMA2-B). RESULTS: FokI polymorphism showed a frequency of 20.1% for homozygous TT carriers and 7.8% for the BsmI GG. The recessive model of FokI (TT genotype) showed a lower mean value of BCF compared to the combination of CC + CT (99.2 vs. 109.6%, p = 0.045). Likewise, significantly lower mean values of HOMA2-B and insulin were observed for BsmI (GG genotype, p = 0.016 and p = 0.039, respectively). After covariates adjustment, only FokI polymorphism remained as an independent predictor of BCF. CONCLUSIONS: the TT and GG variants of the FokI and BsmI polymorphisms are related to a decrease in FCB. In the case of FokI, this decrement was independent of insulin sensitivity, vitamin D levels, percentage of body fat, gender, and age.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Calcitriol / Insulinas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Mexico Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Calcitriol / Insulinas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País/Região como assunto: Mexico Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos