Your browser doesn't support javascript.
loading
Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers.
Berry, Kacey A; Kent, Dorothea; Seetharaman, Srilakshmi; Wong, Randi; Mohamad, Yara; Yao, Frederick; Nunez-Duarte, Maria; Wadhwani, Sharad I; Boyarsky, Brian J; Rahimi, Robert S; Duarte-Rojo, Andres; Kappus, Matthew R; Volk, Michael L; Ladner, Daniela P; Segev, Dorry L; McAdams-DeMarco, Mara; Verna, Elizabeth C; Ganger, Daniel R; Lai, Jennifer C.
Afiliação
  • Berry KA; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Kent D; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Seetharaman S; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Wong R; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Mohamad Y; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Yao F; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Nunez-Duarte M; Johns Hopkins University, Baltimore, MD, United States.
  • Wadhwani SI; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
  • Boyarsky BJ; Johns Hopkins University, Baltimore, MD, United States.
  • Rahimi RS; Baylor University Medical Center at Dallas, Dallas, TX, United States.
  • Duarte-Rojo A; University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
  • Kappus MR; Duke University School of Medicine, Durham, NC, United States.
  • Volk ML; Loma Linda University Adventist Health Sciences Center, Loma Linda, CA, United States.
  • Ladner DP; Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
  • Segev DL; Johns Hopkins University, Baltimore, MD, United States.
  • McAdams-DeMarco M; Johns Hopkins University, Baltimore, MD, United States.
  • Verna EC; Columbia University Irving Medical Center, New York, NY, United States.
  • Ganger DR; Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
  • Lai JC; Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States. Electronic address: jennifer.lai@ucsf.edu.
Ann Hepatol ; 27(5): 100718, 2022.
Article em En | MEDLINE | ID: mdl-35460882
INTRODUCTION: Loneliness, "a subjective feeling of being isolated", is a strong predictor of adverse health. We characterized loneliness in patients with end-stage liver disease (ESLD) awaiting liver transplantation (LT). METHODS: We surveyed loneliness in ambulatory ESLD adults awaiting LT at 7 U.S. sites using the validated UCLA Three-Item Loneliness Scale, May2020-Jan2021; "lonely"=total ≥5. Liver Frailty Index (LFI) assessed frailty; "frail"=LFI≥4.4. Logistic regression associated loneliness and co-variables. RESULTS: Of 454 participants, median MELDNa was 14 (IQR 10-19) and 26% met criteria for "lonely". Compared to those not lonely, those lonely were younger (57 v. 61y), more likely to be female (48% v. 31%) or frail (21 v. 11%), and less likely to be working (15% v. 26%) or in a committed partnership (52% v. 71%). After multivariable adjustment, frailty (OR=2.24, 95%CI=1.23-4.08), younger age (OR=1.19, 95%CI=1.07-1.34), female sex (OR=1.83, 95%CI=1.14-2.92), not working (OR=2.16, 95%CI=1.16-4.03), and not in a committed partnership (OR=2.07, 95%CI=1.29-3.32) remained significantly associated with higher odds of loneliness. CONCLUSION: Loneliness is prevalent in adults awaiting LT, and independently associated with younger age, female sex and physical frailty. These data lay the foundation to investigate the extent to which loneliness impacts health outcomes in LT, as in the general population. Clinical Trial Registry Website: https://clinicaltrials.gov Trial Number: NCT03228290.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Doença Hepática Terminal / Fragilidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Doença Hepática Terminal / Fragilidade Tipo de estudo: Diagnostic_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: México