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Expression of Cytochrome P450 Enzymes in Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas: Possible Role in Carcinogenesis and Treatment Response.
Torres-Zárate, Carmen; Vences-Mejía, Araceli; Espinosa-Aguirre, Jesús Javier; Díaz-Díaz, Eduardo; Palacios-Acosta, José Martín; Cárdenas-Cardós, Rocío; Hernández-Arrazola, Daniel; Shalkow-Klincovstein, Jaime; Jurado, Rodolfo R; Santes-Palacios, Rebeca; Molina-Ortiz, Dora.
Afiliação
  • Torres-Zárate C; Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Vences-Mejía A; Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Espinosa-Aguirre JJ; Instituto de Investigaciones Biomédicas, Universidad Autónoma de México, Mexico City, Mexico.
  • Díaz-Díaz E; Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Palacios-Acosta JM; Servicio de Cirugía Oncológica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Cárdenas-Cardós R; Servicio de Oncología Médica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Hernández-Arrazola D; Servicio de Cirugía Oncológica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Shalkow-Klincovstein J; Servicio de Cirugía Oncológica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Jurado RR; Departamento de Anatomía Patológica, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Santes-Palacios R; Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Molina-Ortiz D; Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Mexico City, Mexico.
Int J Toxicol ; 41(3): 234-242, 2022.
Article em En | MEDLINE | ID: mdl-35437033
The 5-year relative survival rate estimate of treated patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is ∼50% since they generally present with tumor progression, relapse, metastasis, and/or chemoresistance. The expression of cytochrome P450 (CYP) enzymes in malignancies can affect the pharmacology of drugs commonly used in chemotherapy or confer susceptibility to development of chemical carcinogenesis; in addition, their specific tumor expression can be used as a therapeutic target. Using qPCR and Western blot assays, the expression of CYP1B1, CYP2E1, CYP3A4, and CYP3A5 were analyzed in a cohort of tumor tissue paired with non-malignant adjacent tissue of patients with NRSTS. The mRNA and protein expression of CYP1B1, CYP2E1, and CYP3A4 were significantly increased in tumor tissue. We propose that the expression of these isoforms is related to carcinogenesis and chemoresistance frequently observed in these neoplasms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma / Citocromo P-450 CYP3A Limite: Child / Humans Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma / Citocromo P-450 CYP3A Limite: Child / Humans Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos