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Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy.
Campos, Estefânia V R; Proença, Patrícia L F; da Costa, Tais G; de Lima, Renata; Fraceto, Leonardo F; de Araujo, Daniele R.
Afiliação
  • Campos EVR; Human and Natural and Sciences Center, Federal University of ABC, Santo André, SP, Brazil.
  • Proença PLF; Drugs and Bioactives Delivery Systems Research Group-SISLIBIO, Federal University of ABC, Brazil.
  • da Costa TG; São Paulo State University (UNESP), Laboratory of Environmental Nanotechnology, Institute of Science and Technology of Sorocaba, Sorocaba, SP, Brazil.
  • de Lima R; LABiToN (Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials), University of Sorocaba, Sorocaba, SP, Brazil.
  • Fraceto LF; LABiToN (Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials), University of Sorocaba, Sorocaba, SP, Brazil.
  • de Araujo DR; São Paulo State University (UNESP), Laboratory of Environmental Nanotechnology, Institute of Science and Technology of Sorocaba, Sorocaba, SP, Brazil.
Biomed Res Int ; 2022: 9165443, 2022.
Article em En | MEDLINE | ID: mdl-35434138
Topical delivery of local anesthetics (LAs) is commonly used to decrease painful sensations, block pain throughout procedures, and alleviate pain after surgery. Dermal and/or transdermal delivery of LAs has other advantages, such as sustained drug delivery and decreased systemic adverse effects. This study reports the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan for the sustained release and topicality of benzocaine (BZC) and topical delivery. BZC PLGA nanoparticles or nonencapsulated drugs were further incorporated into Poloxamer hydrogels (Pluronic™ F-127). The nanoparticles showed a mean diameter of 380 ± 4 nm, positive zeta potential after coating with chitosan (23.3 ± 1.7 mV), and high encapsulation efficiency (96.7 ± 0.02%). Cellular viability greater than 70% for both fibroblasts and keratinocytes was observed after treatment with nanoparticles, which is in accordance with the preconized guidelines for biomedical devices and delivery systems. Both the nanoparticles and hydrogels were able to modulate BZC delivery and increase drug permeation when compared to the nonencapsulated drug. Furthermore, the incorporation of limonene into hydrogels containing BZC-loaded nanoparticles increased the BZC permeation rates. Non-Newtonian and pseudoplastic behaviors were observed for all hydrogel nanoformulations with or without nanoparticles. These results demonstrate that the hydrogel-nanoparticle hybrids could be a promising delivery system for prolonged local anesthetic therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas Tipo de estudo: Guideline / Risk_factors_studies Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quitosana / Nanopartículas Tipo de estudo: Guideline / Risk_factors_studies Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos