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HLA DQ2/DQ8 haplotypes and anti-transglutaminase antibodies as celiac disease markers in a pediatric population with type 1 diabetes mellitus.
Oliveira, Diana Rita; Rebelo, Joana Freitas; Maximiano, Cristiana; Gomes, Maria Miguel; Martins, Vânia; Meireles, Carla; Antunes, Henedina; Martins, Sofia.
Afiliação
  • Oliveira DR; Serviço de Pediatria, Hospital de Braga, Braga, Portugal, dianarfoliveira@gmail.com.
  • Rebelo JF; Faculdade de Medicina da Universidade do Minho, Braga, Portugal.
  • Maximiano C; Serviço de Pediatria, Hospital de Braga, Braga, Portugal.
  • Gomes MM; Faculdade de Medicina da Universidade do Minho, Braga, Portugal.
  • Martins V; Unidade de Endocrinologia e Diabetologia Pediátrica, Departamento de Pediatria, Hospital de Braga, Braga, Portugal.
  • Meireles C; Serviço de Pediatria, Centro Hospitalar Trás-os-Montes e Alto Douro, Vila Real, Portugal.
  • Antunes H; Serviço de Pediatria, Hospital Senhora da Oliveira-Guimarães, Guimarães, Portugal.
  • Martins S; Unidade de Gastroenterologia, Hepatologia e Nutrição, Serviço de Pediatria e Centro Académico Clínico Hospital de Braga, Braga, Portugal.
Arch Endocrinol Metab ; 66(2): 229-236, 2022 Apr 28.
Article em En | MEDLINE | ID: mdl-35420265
Objective: Evaluate the celiac disease (CD) markers, within the scope of its screening, in a pediatric population with diagnosis of type 1 diabetes (T1D) at Hospital de Braga (HB) and determine the prevalence of CD in the sample. Reflect on CD screening algorithm applied in this pediatric population. Methods: Retrospective observational study with 94 patients diagnosed with T1D at age 10 years or younger, followed up at the HB Outpatient Diabetology Consultation, including those referred from other hospitals. Record of clinical information, IgA anti-transglutaminase and anti-endomysium and HLA DQ2/DQ8 haplotypes. Results: We obtained positive serological test for CD in 4 patients. This test had 100% sensitivity and specificity. The prevalence of CD was 4.3% (n = 4). Positive HLA screening in 84.6% of patients, with both sensitivity and negative predictive value of 100% and specificity of 16.67%. Diagnosis of CD was made on average 3.40 ± 3.32 years after the diagnosis of TD1. All cases of CD registered non-gastrointestinal manifestations, none had gastrointestinal symptoms. Conclusion: This study proved that there is a higher prevalence of CD in pediatric population with TD1, when compared to general population, and clarified the importance of CD screening. Furthermore, it was observed that serological screening for CD antibodies is an excellent screening test and HLA typing, although not the most suitable first line test, can be useful in excluding the possibility of patients with T1D developing CD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Antígenos HLA-DQ / Doença Celíaca / Diabetes Mellitus Tipo 1 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Child / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2022 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Antígenos HLA-DQ / Doença Celíaca / Diabetes Mellitus Tipo 1 Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Child / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2022 Tipo de documento: Article País de publicação: Brasil