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Colostrum Use and the Immune System of Premature Newborns: A Systematic Review and Meta-Analysis.
Colonetti, Tamy; de Carvalho Florêncio, Isabela; Figueiredo, Pâmela; Colonetti, Laura; Rodrigues Uggioni, Maria Laura; da Rosa, Maria Inês; Ceretta, Luciane B; Roever, Leonardo; Grande, Antonio Jose.
Afiliação
  • Colonetti T; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina, Brazil.
  • de Carvalho Florêncio I; Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Mato Grosso do Sul, Brazil.
  • Figueiredo P; Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Mato Grosso do Sul, Brazil.
  • Colonetti L; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina, Brazil.
  • Rodrigues Uggioni ML; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina, Brazil.
  • da Rosa MI; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina, Brazil.
  • Ceretta LB; Universidade do Extremo Sul Catarinense (UNESC), Criciúma, Santa Catarina, Brazil.
  • Roever L; Federal University of Uberlandia, Brazil.
  • Grande AJ; Laboratory of Evidence-Based Practice, Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Mato Grosso do Sul, Brazil.
J Hum Lact ; 38(3): 487-500, 2022 08.
Article em En | MEDLINE | ID: mdl-35416063
BACKGROUND: Human colostrum has been used in a number of investigations when preterm human infants cannot, for any reason, breastfeed directly from their mothers. One of the growing fields in these investigations is colostrum therapy, which consists of exposing the oropharyngeal mucosa of these preterm newborns to small amounts of raw colostrum. RESEARCH AIM: To critically review the scientific evidence about colostrum therapy in premature infants and to explore its influences on the immune system. METHODS: This systematic review was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA statement). The following databases were searched for potentially eligible studies up to March 10, 2021: Medline, Scopus, Web of Science, Cochrane Library, Embase. Two reviewers independently screened all titles, abstracts, and full texts for eligibility. RESULTS: A total of 12 studies with 996 participants were included. A significant difference in lactoferrin levels in the urine was found (SMD 0.70; 95% CI [0.03,1.36]; p = .04; I² = 65% two studies, 112 participants, very low-quality evidence). CONCLUSION: Colostrum seems to result in increasing lactoferrin levels in the urine of premature newborns after 1 week of intervention. CLINICAL TRIAL REGISTRATION: The study was registered at PROSPERO with the number CRD42017073624, submitted on August 9, 2017.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colostro / Doenças do Prematuro Tipo de estudo: Systematic_reviews Limite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: J Hum Lact Assunto da revista: ENFERMAGEM / OBSTETRICIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colostro / Doenças do Prematuro Tipo de estudo: Systematic_reviews Limite: Female / Humans / Infant / Newborn / Pregnancy Idioma: En Revista: J Hum Lact Assunto da revista: ENFERMAGEM / OBSTETRICIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos