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Is Blastocyst Culture Responsible for Higher Pregnancy Rates? A Critical Analysis of the Day of Optimal Embryo Transfer and Embryo Quality.
Günther, Veronika; Dasari-Mettler, Anupama; Mettler, Liselotte; Otte, Sören von; Ackermann, Johannes; Maass, Nicolai; Alkatout, Ibrahim.
Afiliação
  • Günther V; Clinic for Obstetrics and Gynecology, UKSH Campus Kiel, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Dasari-Mettler A; University Fertility Center, Ambulanzzentrum des UKSH gGmbH, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Mettler L; University Fertility Center, Ambulanzzentrum des UKSH gGmbH, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Otte SV; Clinic for Obstetrics and Gynecology, UKSH Campus Kiel, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Ackermann J; University Fertility Center, Ambulanzzentrum des UKSH gGmbH, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Maass N; Clinic for Obstetrics and Gynecology, UKSH Campus Kiel, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
  • Alkatout I; Clinic for Obstetrics and Gynecology, UKSH Campus Kiel, Arnold-Heller-Straße 3 (Haus C), 24105 Kiel, Germany.
JBRA Assist Reprod ; 26(3): 492-499, 2022 08 04.
Article em En | MEDLINE | ID: mdl-35403418
OBJECTIVE: A prolonged culture of embryos beyond day 2-3 to day 5 (blastocyst culture) after fertilization might be an alternative, simple way of selecting suitable embryos for transfer. Extending embryo culture to day 5/6 is a selection tool to choose an embryo with a greater likelihood of implantation rather than improve embryo quality. METHODS: This retrospective study analyzed 1126 fresh IVF/ICSI cycles performed between February 1, 2014 and December 30, 2018 at the University Fertility Center in Kiel, Germany, to determine the impact of blastocyst culture on pregnancy rates and the association between embryo quality and pregnancy rates. RESULTS: Clinical pregnancy was achieved in 154 cases (19.5%) after day 2/3 transfer and in 76 cases (22.7%) after day 5 transfer. Pearson's two-sided chi-squared test yielded no statistical significance (p=0.221). The analysis of clinical pregnancy rates in relation to the quality of transferred embryos yielded the following results: 49 (10.7%) pregnancies in cases of no ideal embryo(s); 122 (27.2%) in cases of at least one ideal embryo; and 59 (26.7%) for both quality groups. Pearson's two-sided Chi-squared test was statistically significant (p<0.001). CONCLUSIONS: Our data revealed no improvement of pregnancy rates after blastocyst transfer compared with day 2/3 transfers. However, we noted higher pregnancy rates when an embryo of good quality was transferred.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Blastocisto / Fertilização in vitro Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Blastocisto / Fertilização in vitro Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Brasil