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Association between beta-2 adrenergic receptor variants and clinical outcomes in children and adolescents with acute asthma.
Muchão, Fábio Pereira; Souza, Andréa Vieira de; Souza, Juliana Miguita E; Silva Filho, Luiz Vicente Ribeiro Ferreira da.
Afiliação
  • Muchão FP; Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Souza AV; Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
  • Souza JME; Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Silva Filho LVRFD; Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo) ; 20: eAO6412, 2022.
Article em En | MEDLINE | ID: mdl-35352766
OBJECTIVE: To investigate whether different genotypes of p.Arg16Gly, p.Gln27Glu, p.Arg19Cys and p.Thr164Ile variants interfere in response to treatment in children and adolescents with moderate to severe acute asthma. METHODS: This sample comprised patients aged 2 to 17 years with a history of at least two wheezing episodes and current moderate to severe asthma exacerbation. All patients received multiple doses of albuterol and ipratropium bromide delivered via pressurized metered-dose inhaler with holding chamber and systemic corticosteroids. Hospital admission was defined as the primary outcome. Secondary outcomes were changes in forced expiratory volume in the first second after 1 hour of treatment, and for outpatients, length of stay in the emergency room. Variants were genotyped by sequencing. RESULTS: A total of 60 patients were evaluated. Hospital admission rates were significantly higher in carriers of the genotype AA relative to those with genotype AG or GG, within the p.Arg16Gly variant (p=0.03, test χ2, alpha=0.05). Secondary outcomes did not differ between genotypes. CONCLUSION: Hospital admission rates were significantly higher among carriers of the genotype AA within the p.Arg16Gly variant. Trial registration: ClinicalTrials.gov: NCT01323010.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Receptores Adrenérgicos beta 2 Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Receptores Adrenérgicos beta 2 Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Einstein (Sao Paulo) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil