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Recurrence of Nephrolithiasis and Surgical Events Are Associated with Chronic Kidney Disease in Adult Patients.
Medina-Escobedo, Martha; Sánchez-Pozos, Katy; Gutiérrez-Solis, Ana Ligia; Avila-Nava, Azalia; González-Rocha, Lizeth; Lugo, Roberto.
Afiliação
  • Medina-Escobedo M; Research Unit, Hospital Regional de Alta Especialidad de la Peninsula de Yucatán, Calle 7 por 20 y 22, Fraccionamiento Altabrisa, Merida 97130, Mexico.
  • Sánchez-Pozos K; Molecular Endocrinology Laboratory, Hospital Juarez de Mexico, Av. Instituto Politecnico Nacional 5160, Gustavo A. Madero, Mexico City 07760, Mexico.
  • Gutiérrez-Solis AL; Research Unit, Hospital Regional de Alta Especialidad de la Peninsula de Yucatán, Calle 7 por 20 y 22, Fraccionamiento Altabrisa, Merida 97130, Mexico.
  • Avila-Nava A; Research Unit, Hospital Regional de Alta Especialidad de la Peninsula de Yucatán, Calle 7 por 20 y 22, Fraccionamiento Altabrisa, Merida 97130, Mexico.
  • González-Rocha L; Research Unit, Hospital Regional de Alta Especialidad de la Peninsula de Yucatán, Calle 7 por 20 y 22, Fraccionamiento Altabrisa, Merida 97130, Mexico.
  • Lugo R; Research Unit, Hospital Regional de Alta Especialidad de la Peninsula de Yucatán, Calle 7 por 20 y 22, Fraccionamiento Altabrisa, Merida 97130, Mexico.
Medicina (Kaunas) ; 58(3)2022 Mar 12.
Article em En | MEDLINE | ID: mdl-35334596
Background and objective: Nephrolithiasis (NL) is a public health problem in the population of Southeast Mexico because of its high prevalence and recurrence. The evolution of this pathology can result in renal damage and may even cause chronic kidney disease (CKD), leading to a reduced glomerular filtration rate (GFR), decreased kidney function, and kidney loss in advanced stages. However, few studies support this evidence in the population. The present study aimed to determine risk factors associated with CKD in adult patients in an endemic population of Mexico. Materials and methods: A case-control study was carried out with patients diagnosed with NL. Additionally, the clinical information of patients (age, weight, height, blood pressure, comorbidities, and time of progress of NL), characteristics of the stones (number, location, and Hounsfield units), and biochemical parameters were collected. Results: The recurrence of NL was associated with CKD (OR 1.91; 95% CI 1.37−2.27; p = 0.003). In addition, male sex (p = 0.016), surgical history (p = 0.011), bilateral kidney stones (p < 0.001), and urinary tract infections (p = 0.004) were other factors associated with CKD. Interestingly, thirty-two patients younger than 50 years old with >2 surgical events presented a significant decrease in GFR (p < 0.001). Conclusions: The recurrence of NL and the number of surgical events were risk factors associated with CKD in patients with NL treated in our population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálculos Renais / Insuficiência Renal Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálculos Renais / Insuficiência Renal Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Suíça