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Investigation on the in vitro anti-Trichophyton activity of photosensitizers.
da Silva, Ana Paula; Uliana, Marciana Pierina; Guimarães, Francisco Eduardo Gontijo; de Oliveira, Kleber Thiago; Blanco, Kate Cristina; Bagnato, Vanderlei Salvador; Inada, Natalia Mayumi.
Afiliação
  • da Silva AP; São Carlos Institute of Physics, University of São Paulo, São Carlos Trabalhador São-carlense Av., 400, São Carlos, São Paulo, 13566-590, Brazil.
  • Uliana MP; Federal University for Latin American Integration, CEP 85866-000, Caixa Postal 2044, Foz do Iguaçu, PR, Brazil.
  • Guimarães FEG; São Carlos Institute of Physics, University of São Paulo, São Carlos Trabalhador São-carlense Av., 400, São Carlos, São Paulo, 13566-590, Brazil.
  • de Oliveira KT; Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil.
  • Blanco KC; São Carlos Institute of Physics, University of São Paulo, São Carlos Trabalhador São-carlense Av., 400, São Carlos, São Paulo, 13566-590, Brazil. blancokate@gmail.com.
  • Bagnato VS; Texas A & University, College Station, TX, USA. blancokate@gmail.com.
  • Inada NM; São Carlos Institute of Physics, University of São Paulo, São Carlos Trabalhador São-carlense Av., 400, São Carlos, São Paulo, 13566-590, Brazil.
Photochem Photobiol Sci ; 21(7): 1185-1192, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35325444
Onychomycosis is the most common disease caused by fungal nail infections, and often caused by dermatophytes. This infection is very resistant to antifungal treatments, and promising Photodynamic Therapy (PDT) mediated treatments has been presented as a multitarget tracking. Optimization of PDT guide for uptake time, concentration of photosensitizers (PS) and the light dose to inactivate Trichophyton mentagrophytes. Curcumin derivatives, porphyrin Chlorin e6 (CHL-E6) and Chlorin-P6-6-N-butylamide-7-methyl-ester (CHL-butyl) were evaluated. PS photobleaching was observed on the hyphae photosensitized over the time, correlating the PS concentration and light dose of antifungal PDT. Porphyrin, Curcumin, Chl-e6 and Chl-butyl concentrations of 2.5 µg/mL, 0.025 µg/mL, 10 µg/mL and 5 µg/mL respectively, under illumination of 10.5 J/cm2 were the best antifungal conditions found in the study. Curcumin, in low concentrations, and chlorin were the PSs with higher activity anti-T. mentagrophytes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Curcumina Idioma: En Revista: Photochem Photobiol Sci Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Curcumina Idioma: En Revista: Photochem Photobiol Sci Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido