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Familial breast cancer, pregnancy and cardiotoxicity associated with the use of doxorubicin and reaction with trastuzumab.
Valente, Patricia Marques Soares; Gomes, Magda Conceição Barbosa; Martins, Wolney de Andrade; Castilho, Selma Rodrigues de.
Afiliação
  • Valente PMS; Posgraduate Program in Sciences Applied to Health Products, 28110Fluminense Federal University, Niterói, RJ, Brazil.
  • Gomes MCB; 219791Antonio Pedro University. Hospital. Fluminense Federal University, Niterói, RJ, Brazil.
  • Martins WA; 219791Antonio Pedro University. Hospital. Fluminense Federal University, Niterói, RJ, Brazil.
  • Castilho SR; Posgraduate Program in Sciences Applied to Health Products, 28110Fluminense Federal University, Niterói, RJ, Brazil.
J Oncol Pharm Pract ; 28(8): 1893-1897, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35321591
INTRODUCTION: Breast Cancer (BC) is a neoplasm with the highest prevalence in women in Brazil and worldwide. Pregnancy-associated with BC is defined as that which occurs during pregnancy or within 1 to 2 years postpartum. The objective is to present a clinical case of a young patient with a history of familial BC who had cancer during pregnancy. The patient had cardiotoxicity after using doxorubicin and trastuzumab. CASE REPORT: She was a young patient within infiltrating ductal carcinoma in the right breast She was diagnosed within nine weeks of gestation and submitted to neoadjuvant chemotherapy with AC protocol (doxorubicina and cyclophosphamide) and mastectomy. Developed left atrial overload after treatment and still responding to hypersensitivity to trastuzumab. MANAGEMENT AND OUTCOME: The patient presented an alteration in the electrocardiogram (ECG) after the use of doxorubicin. The exam was repeated and the ECG was normal. Trastuzumab was started after delivery and the patient had a hypersensitivity reaction. Administration of trastuzumab was stopped and hydrocortisone was administered. The patient showed improvement in symptoms with cessation of trastuzumab. DISCUSSION: Although anthracycline-induced cardiotoxicity and hypersensitivity reactions to trastuzumab are common reactions, there are few studies on the effects of these drugs in patients with Gestational breast cancer (GBC). Monitoring cardiotoxicity in breast cancer treatment in pregnant patients is essential to avoid two complications: for the pregnant woman and the fetus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Oncol Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Oncol Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido