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Efficacy of oral fluralaner (Bravecto) against Tunga penetrans in dogs: A negative control, randomized field study in an endemic community in Brazil.
Dos Santos, Katharine Costa; Chiummo, Rafael Marin; Heckeroth, Anja Regina; Zschiesche, Eva; Brandão Guedes, Paula Elisa; Harvey, Tatiani Vitor; de Jesus, Anderson Vieira; da Paixão Sevá, Anaiá; de Oliveira, Joana Thaisa Santos; Dos Santos Freire, Zelina; Krücken, Jürgen; de Almeida Borges, Fernando; von Samson-Himmelstjerna, Georg; Alberto Carlos, Renata Santiago.
Afiliação
  • Dos Santos KC; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • Chiummo RM; MSD, Animal Health Innovation GmbH, Schwabenheim, Germany.
  • Heckeroth AR; MSD, Animal Health Innovation GmbH, Schwabenheim, Germany.
  • Zschiesche E; MSD, Animal Health Innovation GmbH, Schwabenheim, Germany.
  • Brandão Guedes PE; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • Harvey TV; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • de Jesus AV; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • da Paixão Sevá A; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • de Oliveira JTS; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil.
  • Dos Santos Freire Z; UFMS, Federal University of Mato Grosso do Sul, Faculty of Veterinary Medicine and Animal Science, Campo Grande, Mato Grosso do Sul, Brazil.
  • Krücken J; Freie Universität Berlin, Institute for Parasitology and Tropical Veterinary Medicine, Berlin, Germany.
  • de Almeida Borges F; UFMS, Federal University of Mato Grosso do Sul, Faculty of Veterinary Medicine and Animal Science, Campo Grande, Mato Grosso do Sul, Brazil.
  • von Samson-Himmelstjerna G; Freie Universität Berlin, Institute for Parasitology and Tropical Veterinary Medicine, Berlin, Germany.
  • Alberto Carlos RS; UESC, State University of Santa Cruz, Department of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, Ilhéus, Bahia, Brazil. CNPq Reseracher - PQ2.
PLoS Negl Trop Dis ; 16(3): e0010251, 2022 03.
Article em En | MEDLINE | ID: mdl-35286319
The sand flea Tunga penetrans is one of the zoonotic agents of tungiasis, a parasitic skin disease of humans and animals. The dog is one of its main reservoirs. This negatively controlled, randomized, double-masked clinical trial evaluated the therapeutic and residual efficacy of fluralaner for treatment of dogs naturally infested with T. penetrans. Sixty-two dogs from an endemically affected community in Brazil were randomly assigned to either receive oral fluralaner (Bravecto chewable tablets) at a dose of 25 to 56 mg fluralaner/kg body weight, or no treatment (31 dogs per group). Dogs were clinically examined using a severity score for acute canine tungiasis (SCADT), parasitological examinations as defined by the Fortaleza classification, and pictures of lesions on days 0 (inclusion and treatment), 7 ± 2, 14 ± 2, 21 ± 2, 28 ± 2, 60 ± 7, 90 ± 7, 120 ± 7 and 150 ± 7. The percentage of parasite-free dogs after treatment was >90% between days 14 and 90 post-treatment with 100% efficacy on study days 21, 28 and 60. Sand flea counts on fluralaner treated dogs were significantly lower (p<0.025) than control dogs on all counts from day 7 to 120. The number of live sand fleas on treated dogs was reduced by > 90% on day 7, > 95% on days 14 and 90, and 100% from day 21 to 60, and with a significant difference between groups from day 7 to 120. From day 7 to day 120, mean SCADT scores were significantly reduced in treated dogs with a mean of 0.10 compared to 1.54 on day 120 in untreated dogs. Therefore, a single oral fluralaner administration is effective for treating and achieving long lasting (> 12 weeks) prevention for tungiasis in dogs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Tungíase / Inseticidas Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Tungíase / Inseticidas Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos