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Variants in the VDR Gene May Influence 25(OH)D Levels in Type 1 Diabetes Mellitus in a Brazilian Population.
Ferraz, Rafaella S; Silva, Caio S; Cavalcante, Giovanna C; de Queiroz, Natércia N M; Felício, Karem M; Felício, João S; Ribeiro-Dos-Santos, Ândrea.
Afiliação
  • Ferraz RS; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil.
  • Silva CS; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil.
  • Cavalcante GC; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil.
  • de Queiroz NNM; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil.
  • Felício KM; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil.
  • Felício JS; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil.
  • Ribeiro-Dos-Santos Â; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil.
Nutrients ; 14(5)2022 Feb 27.
Article em En | MEDLINE | ID: mdl-35267984
Vitamin D has been considered a strong contributing factor to type 1 diabetes mellitus (T1DM). Many studies have investigated polymorphisms in the VDR gene in association with T1DM in different populations, but there are still conflicting findings. This study aimed to evaluate the association of four variants in the VDR gene (rs7975232, rs1544410, rs731236, and rs2228570) with T1DM risk and vitamin D levels within a population from North Region, Brazil, as well as the influence of genomic ancestry on T1DM. A total of 65 T1DM patients and 83 non-T1DM patients were enrolled in this study. VDR gene polymorphisms were assessed using Sanger sequencing analysis. Genomic ancestry was analyzed using a set of 61 ancestry-informative markers. T1DM patients showed higher European genomic contribution and lower Native American genomic contribution when compared to non-T1DM patients. T1DM patients with AA genotype in rs1544410 or CC genotype in rs731236 had significantly lower 25(OH)D levels compared to the other two genotypes (p = 0.013 and p = 0.02, respectively), while T1DM with TT genotype in rs2228570 had higher 25(OH)D levels compared to CC + TC in the same polymorphism (p = 0.011). Our findings suggest that the association between 25(OH)D and T1DM may be modified by VDR variants, possibly influencing the development of this autoimmune disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Nutrients Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça