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Triple-negative breast cancer treatment in xenograft models by bifunctional nanoprobes combined to photodynamic therapy.
Dos Santos Jesus, Viviane Paula; Vieira, Paula Fonseca Antunes; Cintra, Ricardo Cesar; Sant'Anna, Luciana Barros; Zezell, Denise Maria; Castilho, Maiara Lima; Raniero, Leandro.
Afiliação
  • Dos Santos Jesus VP; Nanosensors Laboratory, Research and Development Institute, University of Vale do Paraíba, UNIVAP, Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, São Paulo 12244-000, Brazil.
  • Vieira PFA; Nanosensors Laboratory, Research and Development Institute, University of Vale do Paraíba, UNIVAP, Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, São Paulo 12244-000, Brazil.
  • Cintra RC; Biochemistry Department, Universidade de São Paulo, USP, São Paulo, Brazil.
  • Sant'Anna LB; Histology and Regenerative Therapy Laboratory, Research and Development Institute, University of Vale do Paraíba, UNIVAP, São Paulo, Brazil.
  • Zezell DM; Energetics and Nuclear Research Institute, IPEN, Universidade de São Paulo, USP, São Paulo, Brazil.
  • Castilho ML; Bionanotecnology Laboratory, Research and Development Institute, University of Vale do Paraíba, UNIVAP, São Paulo, Brazil.
  • Raniero L; Nanosensors Laboratory, Research and Development Institute, University of Vale do Paraíba, UNIVAP, Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, São Paulo 12244-000, Brazil. Electronic address: lraniero@univap.br.
Photodiagnosis Photodyn Ther ; 38: 102796, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35263669
Triple-negative breast cancer (TNBC) overexpresses the Epidermal Growth Factor Receptor (EGFR), a characteristic of different types of tumors, linked to worse disease prognosis and risk of recurrence. Conventional treatments are also aggressive and can be morbid.. Therefore, t improvement and development of new methods are notorious. Photodynamic Therapy (PDT) is an effective method for treating different types of cancer by using light radiation to activate a photosensitizing agent (drug) in molecular oxygen presence, promoting cell death., Improving drug uptake in target cells could contribute to PDT efficiency. Accordingly, we developed a bifunctional nanoprobe (BN), used in PDT as a a treatment method in vivo against breast cancer. The BN uses gold nanoparticles with active targeting through the Epidermal Growth Factor (EGF) protein and Chlorine e6 (Ce6) carriers. We evaluated the therapeutic efficacy of in vivo xenograft in 4 groups: Saline, BN, Ce6+PDT, and BN+PDT. As a result, we observed that the BN+PDT group exhibited an excellent effect with greater selectivity to tumor tissue and tissue damage when compared to the Saline, BN, and Ce6+PDT groups. The results indicate a potential impact on breast cancer treatment in vivo.. In conclusion, our data propose that the BN developed heightened PDT efficacy through cellular DNA repair effects and tumor microenvironment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Clorofilídeos / Nanopartículas / Nanopartículas Metálicas / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Clorofilídeos / Nanopartículas / Nanopartículas Metálicas / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Photodiagnosis Photodyn Ther Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda