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Influence of exercise and vitamin D on the immune system against Covid-19: an integrative review of current literature.
Bizuti, Matheus Ribeiro; Starck, Édina; da Silva Fagundes, Kimberly Kamila; Puhle, Josiano Guilherme; Lima, Lucas Medeiros; de Oliveira, Natan Rodrigues; de Sousa Silva, Guilherme Vinicio; Silva, Débora Tavares Resende E.
Afiliação
  • Bizuti MR; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • Starck É; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • da Silva Fagundes KK; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • Puhle JG; The Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • Lima LM; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • de Oliveira NR; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • de Sousa Silva GV; Department of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • Silva DTRE; Department of Pathology. Graduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Fronteira Sul, Highway SC 484 - Km 02, Chapecó, Santa Catarina, 89815-899, Brazil. debora.silva@uffs.edu.br.
Mol Cell Biochem ; 477(6): 1725-1737, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35258807
Respiratory infections of viral origin have become the leading cause of infectious diseases in the world. In 2020, the World Health Organization (WHO) declared a pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (Covid-19). The pandemic caused by the new coronavirus has challenged the entire global health system, since Covid-19 has a high rate of morbidity and mortality. The immune response to the virus depends on factors such as age, genetics, nutritional status, physical status, as well as environmental factors. Despite scientific advances, so far, there is still no specific therapy for the disease. Thus, this study aims to analyze the contribution of physical exercise and maintenance and/or supplementation of vitamin D to the strengthening of the immune system against viral infections, among them, Covid-19. Regular practice of moderate-intensity physical activity is responsible for promoting a reduction in the concentrations of pro-inflammatory cytokines (IL-6, TNF-α and IL-1ß), as well as triggering the increase in the production of anti-inflammatory cytokines (IL-4 and IL-10). In addition, hypovitaminosis D predisposes to the development of chronic diseases and infections. Therefore, in patients affected by Covid-19, the maintenance of vitamin D levels contributes significantly to the 0prevention of the cytokine storm. Thus, the association between maintaining vitamin D levels and performing moderate-intensity physical exercise is responsible for strengthening the immune system and, therefore, triggering a defense mechanism against infections by intracellular microorganisms, in which SARS -CoV-2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda