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Prophylaxis for invasive fungal infection in pediatric patients with allogeneic hematopoietic stem cell transplantation.
Perez, Paola; Patiño, Jaime; Franco, Alexis A; Rosso, Fernando; Beltran, Estefania; Manzi, Eliana; Castro, Andrés; Estacio, Mayra; Valencia, Diego Medina.
Afiliação
  • Perez P; Universidad Icesi, Facultad de Ciencias de la Salud, Colombia.
  • Patiño J; Fundación Valle del Lili, Departamento Materno-infantil, Servicio de Infectología Pediátrica, Colombia.
  • Franco AA; Universidad Icesi, Facultad de Ciencias de la Salud, Colombia.
  • Rosso F; Fundación Valle del Lili, Departamento Materno-infantil, Servicio de Infectología Pediátrica, Colombia.
  • Beltran E; Universidad Icesi, Facultad de Ciencias de la Salud, Colombia.
  • Manzi E; Fundación Valle del Lili, Departamento Materno-infantil, Unidad de Trasplante de Médula Ósea, Colombia.
  • Castro A; Universidad Icesi, Facultad de Ciencias de la Salud, Colombia.
  • Estacio M; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cali, Colombia.
  • Valencia DM; Fundación Valle del Lili, Centro de Investigaciones Clínicas (CIC), Cali, Colombia.
Blood Res ; 57(1): 34-40, 2022 Mar 31.
Article em En | MEDLINE | ID: mdl-35256547
Background: Antifungal prophylaxis is recommended for hematopoietic stem cell transplantation (HSCT) to decrease the incidence of invasive fungal infections (IFI). This study aimed to compare the two groups of antifungal prophylaxis in pediatric patients undergoing allogeneic HSCT. Methods: This observational, analytic, retrospective cohort study compared the incidence of IFI with antifungal prophylaxis with voriconazole vs. other antifungals in the first 100 days after allogeneic HSCT in patients aged <18 years between 2012 and 2018. The statistical analysis included univariate and multivariate analyses and determination of the cumulative incidence of invasive fungal infection by the Kaplan‒Meier method using STATA 14 statistical software. Results: A total of 139 allogeneic HSCT were performed. The principal diagnosis was acute leukemia (63%). The 75% had haploidentical donors, and 50% used an antifungal in the month before transplantation. Voriconazole (69%) was the most frequently administered antifungal prophylaxis. The cumulative incidence of IFI was 5% (7 cases). Of the patients with IFIs, four began prophylaxis with voriconazole, one with caspofungin, and one with fluconazole. Additionally, six were possible cases, one was proven (Candida parapsilosis), and 1/7 died. Conclusion: There were no differences in the incidence of IFI between patients who received prophylaxis with voriconazole and other antifungal agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Blood Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação:
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Blood Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: