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Campimetry and visual changes after RHZE treatment for tuberculosis.
Taffner, Brunella Maria Pavan; da Cruz, Luiz Guilherme Ito; de Ávila Fowler, Flávio; Nawa, Carolynne Cardoso; Savioli, Marcia Telma; Rodrigues, Denise Silva; Magalhães Junior, Octaviano; Belfort Junior, Rubens.
Afiliação
  • Taffner BMP; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil. brunellapavan@gmail.com.
  • da Cruz LGI; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil.
  • de Ávila Fowler F; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil.
  • Nawa CC; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil.
  • Savioli MT; Departament of Pneumology, Federal University of São Paulo, UNIFESP, São Paulo, Brazil.
  • Rodrigues DS; Departament of Infectology, Instituto Clemente Ferreira, São Paulo, Brazil.
  • Magalhães Junior O; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil.
  • Belfort Junior R; Departament of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, SP, Botucatu, 822, Vila Clementino, Brazil.
Int J Retina Vitreous ; 8(1): 16, 2022 Mar 07.
Article em En | MEDLINE | ID: mdl-35256005
BACKGROUND: Tuberculosis (TB) caused by Mycobacterium tuberculosis has a high prevalence in Brazil (Global tuberculosis report 2020. Geneva: World Health Organization; 2020). The ethambutol-induced optic neuropathy damage is partly reversible, making its early diagnosis essential to reduce permanent visual damage. PURPOSE: To observe alterations in the computerized campimetry, Ishihara test and visual acuity secondary to rifampicin, isoniazid, pyrimethamine, ethambutol (RHZE) treatment. METHODS: Patients undergoing treatment with RHZE at the tuberculosis service of the Federal University of São Paulo were recruited from March 2019 to December 2020. The best-corrected visual acuity (VA) measurements, Ishihara test and visual fields were performed at baseline, monthly, until 2 weeks after treatment. RESULTS: Twenty-five patients were included. The VA decreased significantly (P = 0.0129) post-treatment compared to month 1. The mean deviation (MD) did not decrease significantly (P > 0.05); the pattern standard deviation (PSD) decreased post-treatment compared to month 1 (P = 0.0371). Changes in the Ishihara test increased significantly (P < 0.0001) in the second month. CONCLUSION: The VA and PSD decreased significantly after RHZE treatment. Changes in the Ishihara test were observed in the second month. TRIAL REGISTRATION: The Research Ethics Committee of Federal University of São Paulo, Paulista School of Medicine approved the study in March 2019. CAAE 04297018.4.0000.5505.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies / Screening_studies Aspecto: Ethics Idioma: En Revista: Int J Retina Vitreous Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies / Screening_studies Aspecto: Ethics Idioma: En Revista: Int J Retina Vitreous Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido