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Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient.
Pontes, Laís; Gualtieri Beraquet, Caio Augusto; Arai, Teppei; Watanabe, Akira; Moretti, Maria Luiza; Schreiber, Angelica Zaninelli.
Afiliação
  • Pontes L; School of Medical Sciences - University of Campinas, Campinas, Sao Paulo, Brazil.
  • Gualtieri Beraquet CA; School of Medical Sciences - University of Campinas, Campinas, Sao Paulo, Brazil.
  • Arai T; Division of Clinical Research, Medical Mycology Research Center - Chiba University, Chiba, Japan.
  • Watanabe A; Division of Clinical Research, Medical Mycology Research Center - Chiba University, Chiba, Japan.
  • Moretti ML; School of Medical Sciences - University of Campinas, Campinas, Sao Paulo, Brazil.
  • Schreiber AZ; School of Medical Sciences - University of Campinas, Campinas, Sao Paulo, Brazil.
Med Mycol Case Rep ; 36: 5-9, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35242508
We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with the same genotypic characteristics, but with an increase in MIC for several azoles. The two last isolates presented high MICs for Voriconazole (>8 µg/mL>). Sequencing of the CYP51A gene showed G448S amino acid substitution in the same two isolates. In long-term treatments with antifungals, it would be important to regularly evaluate the susceptibility of isolated strains, as resistance to azoles has been increasingly described around the world.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Med Mycol Case Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Med Mycol Case Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda