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Serum Syndecan-1 levels in patients with immunoglobulin A vasculitis in children.
Jia, Xinyi; Zhu, Zhenya; Miao, Jing; Zhang, Linqian; Li, Xiaobing; Bao, Yunguang; Jiang, Mizu.
Afiliação
  • Jia X; Gastrointestinal Lab, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China; Jinhua Hospital, Zhejiang University and Jinhua Municipal Central Hospital, Jinhua, China; En
  • Zhu Z; Gastrointestinal Lab, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China.
  • Miao J; Gastrointestinal Lab, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China; Jinhua Hospital, Zhejiang University and Jinhua Municipal Central Hospital, Jinhua, China.
  • Zhang L; Jinhua Hospital, Zhejiang University and Jinhua Municipal Central Hospital, Jinhua, China.
  • Li X; Jinhua Hospital, Zhejiang University and Jinhua Municipal Central Hospital, Jinhua, China.
  • Bao Y; Jinhua Hospital, Zhejiang University and Jinhua Municipal Central Hospital, Jinhua, China.
  • Jiang M; Gastrointestinal Lab, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China; Endoscopy center and Department of Gastroenterology, Children's Hospital, Zhejiang University
J Pediatr (Rio J) ; 98(5): 526-532, 2022.
Article em En | MEDLINE | ID: mdl-35240047
OBJECTIVE: The aim of this study was to evaluate the serum Syndecan-1 (SDC-1) levels in patients with immunoglobulin-A vasculitis (IgAV) in children and its relation with gastrointestinal involvements. METHODS: Sixty-eight children with IgAV and 48 healthy children were enrolled in this cross-sectional study. Clinical and related laboratory data were collected from a computerized hospital database. Serum SDC-1 was collected on admission prior to treatment. RESULTS: Forty-eight patients fully met the IgAV diagnostic criteria at admission (IgAV group), 20 patients with rash only and diagnosed IgAV during hospitalization (Purpura group). In IgAV group, 30 patients with gastrointestinal involvements (IgAV-GI group) and 18 patients without gastrointestinal involvements (IgAV-NGI group). SDC-1 serum levels were significantly higher in the IgAV group (86.37 ng/mL (IQR 59.16-117.14 ng/mL)) than in the controls (20.37 ng/mL (IQR 15.52-26.45 ng/mL)) and the Purpura group (32.66 ng/mL (IQR 14.87-49.89 ng/mL)). Additionally, SDC-1 (OR = 1.08) was independently associated with IgAV with a cut-off value (sensitivity and specificity) of 66.55 ng/mL (68.8%, 95.0%), and the area under the curve was 0.908. The serum SDC-1 levels of the IgAV-GI group (106.92 ± 50.12 ng/mL) were significantly higher than those in the IgAV-NGI group (67.52 ± 17.59 ng/mL). Logistic regression analysis showed that SDC-1 (OR = 1.03) was independently associated with IgAV-GI with a cut-off value of 89.39 ng/mL. CONCLUSIONS: SDC-1 serum levels may mirror vascular endothelium injury and mucosal damage in IgAV. Its applicability as a surrogate biomarker in IgAV remains to be determined.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite por IgA / Sindecana-1 Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2022 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite por IgA / Sindecana-1 Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2022 Tipo de documento: Article País de publicação: Brasil