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Mortality associated with cysticercosis in a historical cohort from Britain.
Singh, Gagandeep; Chiodini, Peter; Sander, Josemir W.
Afiliação
  • Singh G; Dayanand Medical College, Department of Neurology, Ludhiana, India.
  • Chiodini P; University College London, Hospitals Biomedical Research Centre, Queen Square Institute of Neurology, London, WC1N 3BG, UK.
  • Sander JW; Hospital for Tropical Diseases and London School of Hygiene and Tropical Medicine, Department of Clinical Parasitology, London, UK.
Arq Neuropsiquiatr ; 80(3): 248-254, 2022 03.
Article em En | MEDLINE | ID: mdl-35239816
BACKGROUND: The burden of premature mortality associated with human cysticercosis is largely ignored mainly due to poor record-keeping in Taenia solium endemic regions. OBJECTIVE: To document mortality and survival characteristics of an historical cohort with cysticercosis. METHODS: The years of onset of symptoms and death untill 1957 were extracted from published reports of a British military cohort (n=450) examined in London in the early twentieth century. Data were entered into a Kaplan Meier survival analysis with the presence (or absence) of clinical manifestations as independent variables, which were then fitted into a Cox proportional hazards model to determine their significance. RESULTS: Cysticercosis was responsible for 24 (52.2%) of 46 deaths in the first 15 years of follow-up in comparison to 7 (19.4%) of 36 deaths in the 20-40 years of follow-up period. In the univariate and Cox analyses, intracranial hypertension (hazard ratio [HR]: 8.26; CI: 4.71, 14.49), ocular cysticercosis (HR: 6.60; CI: 3.04, 14.33), and mental disorder (HR: 3.98; CI: 2.22, 7.13) but not epilepsy (HR: 0.66; CI: 0.20, 2.18) were associated with mortality. Over half of all deaths in the first 15 years of follow-up were attributed to cysticercosis. CONCLUSIONS: Several deaths occurred early after acquiring cysticercotic infection. Intracranial hypertension, ocular cysticercosis, and mental disorder but not epilepsy were predictors of mortality in this cohort.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisticercose / Hipertensão Intracraniana / Taenia solium / Epilepsia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Europa Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisticercose / Hipertensão Intracraniana / Taenia solium / Epilepsia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Europa Idioma: En Revista: Arq Neuropsiquiatr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia País de publicação: Alemanha