Your browser doesn't support javascript.
loading
Venous Thromboembolism in Patients with Cancer Receiving Specialist Palliative Care.
Allende-Pérez, Silvia Rosa; Cesarman-Maus, Gabriela; Peña-Nieves, Adriana; Arcos, Amelia; Baz-Gutiérrez, Patricia; Robles, Joanna; LeBlanc, Thomas W.
Afiliação
  • Allende-Pérez SR; Palliative Care Service, National Cancer Institute, Mexico City, Mexico.
  • Cesarman-Maus G; Hematology Service, National Cancer Institute, Mexico City, Mexico.
  • Peña-Nieves A; Palliative Care Service, National Cancer Institute, Mexico City, Mexico.
  • Arcos A; Palliative Care Service, Mexican Secretariat of the Navy, Mexico City, Mexico.
  • Baz-Gutiérrez P; Hematology Service, National Cancer Institute, Mexico City, Mexico.
  • Robles J; 12277Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
  • LeBlanc TW; Department of Medicine, Hematologic malignancies and cellular therapy, Duke University School of Medicine Durham, Durham, North Carolina, USA.
Clin Appl Thromb Hemost ; 28: 10760296221081121, 2022.
Article em En | MEDLINE | ID: mdl-35225029
CONTEXT: The prevalence of venous thromboembolism (VTE) in patients with cancer is particularly high at disease progression and during relapse. Patients cared for in specialized palliative care units (SPCU) are rarely included in VTE studies. Objective: We sought to study the prevalence, clinical characteristics, and survival of individuals with VTE in an SPCU setting. METHODS: We retrospectively included 2707 consecutive individuals with active cancer managed at a SPCU. Data were summarized using descriptive statistics and frequency for categorical variables. Overall survival was estimated by Kaplan-Meier and comparisons by log-rank test. Thrombotic events were confirmed by imaging. RESULTS: We studied 1984(73.3%) women and 723 (26.7%) men. The overall prevalence of thrombosis was 22.2% with only 6.2% occurring after initiating SPCU care, and was higher in women (24.6% vs 15.8%), particularly with gynecological tumors (cervical: 30.5%, ovarian: 29.2%). Median survival was slightly longer for patients without VTE (80 days [IQR21-334] and 69 days [IQR 25-235]; p = 0.03). CONCLUSIONS: Prevalence of VTE was high and varied by tumor origin. VTE may impact survival. Though median survival is short, some patients are followed over months, suggesting that in the absence of high bleeding risk, treatment for thrombosis in an attempt to decrease the morbidity of re-thrombosis should be considered. On the other hand, few patients developed symptomatic VTE during SPCU care, making generalized primary prophylaxis probably unwarranted. Customizing anticoagulation for the risk of hemorrhage and physical performance is essential.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cuidados Paliativos / Tromboembolia Venosa / Anticoagulantes / Neoplasias Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Clin Appl Thromb Hemost Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cuidados Paliativos / Tromboembolia Venosa / Anticoagulantes / Neoplasias Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Clin Appl Thromb Hemost Assunto da revista: ANGIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos