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Epstein-Barr Virus (EBV) Genotypes Associated with the Immunopathological Profile of People Living with HIV-1: Immunological Aspects of Primary EBV Infection.
Pereira, Leonn Mendes Soares; França, Eliane Dos Santos; Costa, Iran Barros; Lima, Igor Tenório; Freire, Amaury Bentes Cunha; Ramos, Francisco Lúzio de Paula; Monteiro, Talita Antonia Furtado; Macedo, Olinda; Sousa, Rita Catarina Medeiros; Freitas, Felipe Bonfim; Brasil Costa, Igor; Vallinoto, Antonio Carlos Rosário.
Afiliação
  • Pereira LMS; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
  • França EDS; Epstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Costa IB; Epstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Lima IT; Epstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Freire ABC; Epidemiology and Surveillance Service, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Ramos FLP; Epidemiology and Surveillance Service, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Monteiro TAF; Epstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Macedo O; Retrovirus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Sousa RCM; School of Medicine, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
  • Freitas FB; Retrovirus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Brasil Costa I; Epstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
  • Vallinoto ACR; Graduate Program in Virology, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Viruses ; 14(2)2022 01 18.
Article em En | MEDLINE | ID: mdl-35215762
BACKGROUND: The aim of the present study was to evaluate the immunological profile of adult HIV-1+ patients coinfected with primary Epstein-Barr virus (EBV) infection who were free of antiretroviral drugs and inhabitants of the Brazilian Amazon region. MATERIALS AND METHODS: Primary EBV infection was screened by the semiquantitative detection of IgM and IgG anti-VCA. Genotypes were determined by conventional PCR. EBV and HIV viral load (VL) were quantified by real-time PCR. Cytokine dosage and cell quantification were performed by cytometry. RESULTS: Only HIV-1+ individuals had primary EBV infection (7.12%). The EBV-1 genotype was the most prevalent (47.37%). The VL of HIV-1 was lower in the HIV/EBV-2 group. CD4+ T lymphocytes were inversely proportional to the VL of EBV in HIV/EBV-1/2 multi-infected patients. The HIV/EBV-2 group had the lowest cytokine levels, especially IFN-γ and IL-4. Different correlations were proposed for each coinfection. The late search for specific care related to HIV infection directly affected the cytokine profile and the number of CD8+ T lymphocytes. Symptoms were associated with the increase in VL of both viruses and cytokine profile. CONCLUSIONS: Different immunological profiles were associated with EBV genotypes in primary infection, with EBV-2 being more frequent in patients with low levels of HIV viral load. With late infection monitoring and consequent delay in the initiation of HAART, clinical changes and effects on the maintenance of the immune response were observed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Viruses Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Viruses Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça