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Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer.
Zambalde, Erika Pereira; Adamoski, Douglas; Gradia, Daniela Fiori; Rabinovich, Iris; Rodrigues, Ana Carolina; Ivan, Cristina; Ribeiro, Enilze M S F; Calin, George Adrian; Carvalho de Oliveira, Jaqueline.
Afiliação
  • Zambalde EP; Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil.
  • Adamoski D; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas 13083-970, SP, Brazil.
  • Gradia DF; Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil.
  • Rabinovich I; Hospital Nossa Senhora das Graças, Centro de Doenças da Mama, Curitiba 80810-040, PR, Brazil.
  • Rodrigues AC; Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil.
  • Ivan C; Translational Molecular Pathology Department, The University of Texas MD Anderson Cancer Center, TX 77230, USA.
  • Ribeiro EMSF; Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil.
  • Calin GA; Translational Molecular Pathology Department, The University of Texas MD Anderson Cancer Center, TX 77230, USA.
  • Carvalho de Oliveira J; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
Biomolecules ; 12(2)2022 01 26.
Article em En | MEDLINE | ID: mdl-35204715
Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp, that are 100% conserved among humans, mice, and rats. The majority of UCRs are transcriptionally active (T-UCRs) as many of them produce non-coding RNAs. In a previous study, we evaluated the expression level of T-UCRs in breast cancer (BC) patients and found that 63% of transcripts correlated with some clinical and/or molecular parameter of BC. In this study, we delved into the expression levels of 12 T-UCRs and correlated them with clinicopathological parameters, immunohistochemical markers, and overall survival in two breast cancer cohorts: TCGA and Brazilian patients. We found that uc.268 is more expressed in TCGA patients under 40 years of age, associated with progesterone receptor (PR) and estrogen receptor (ER), and its high expression is found in luminal A. Lower uc.84 and uc.376 were respectively observed in metastatic and stage IV tumors associated with good prognostic in luminal B. Moreover, uc.84 was only related to the HER2+, while uc.376 was related to ER+ and PR+, and HER2+. A panel composed of uc.147, uc.271, and uc.427 distinguished luminal A from triple negative patients with an AUC of 0.9531 (sensitivity 92.19% and specificity 86.76%). These results highlight the potential role of T-UCRs in BC and provide insights into the potential application of T-UCRs as biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça