Your browser doesn't support javascript.
loading
The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans.
Bailone, Ricardo Lacava; Fukushima, Hirla Costa Silva; de Aguiar, Luis Kluwe; Borra, Ricardo Carneiro.
Afiliação
  • Bailone RL; Department of Genetic and Evolution, Federal University of São Carlos, Washington Luiz Road, km 230, São Carlos City, São Paulo County, 13565-905, Brazil. ricardo.bailone@agricultura.gov.br.
  • Fukushima HCS; Department of Federal Inspection Service, Federal Inspection Service, Ministry of Agriculture, Livestock and Supply of Brazil, Brasília, Brazil. ricardo.bailone@agricultura.gov.br.
  • de Aguiar LK; Centre of Biological and Health Sciences, Federal University of Sao Carlos, São Carlos, Brazil.
  • Borra RC; Department of Food, Land and Agribusiness Management, Harper Adams University, Newport, England.
Lab Anim Res ; 38(1): 5, 2022 Feb 22.
Article em En | MEDLINE | ID: mdl-35193700
Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors (CB1 and CB2). The zebrafish model is a promising one for the study of cannabinoids because of the many similarities to the human system. Despite the recent advances on the eCB system, there is still the need to elucidate some of the interactions and, thus, the zebrafish model can be used for that purpose as it respects the 3Rs concept and reduced time and costs. In view of the relevance of cannabinoids in the treatment and prevention of diseases, as well as the importance of the zebrafish animal model in elucidating the biological effects of new drugs, the aim of this study was to bring to light information on the use of the zebrafish animal model in testing C. sativa-based medicines.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Lab Anim Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Lab Anim Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido