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Venetoclax-based combinations for acute myeloid leukemia: optimizing their use in Latin-America.
Gómez-De León, Andrés; Demichelis-Gómez, Roberta; Pinedo-Rodríguez, Alfredo; Enriquez-Vera, Daniel; Flores-Jiménez, Juan Antonio; Ceballos-López, Adrián Alejandro; Rodríguez-Mejorada, Margarita; Herrera Riojas, Miguel Angel; Ovilla-Martínez, Roberto; Báez-Islas, Pamela; Cota-Rangel, Xóchitl; Neme-Yunes, Yvette; Inclán-Alarcón, Sergio; López-Flores, Nelson J; Colunga-Pedraza, Perla R; Rodríguez-Zúñiga, Anna C; Gómez-Almaguer, David.
Afiliação
  • Gómez-De León A; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
  • Demichelis-Gómez R; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, CDMX, Mexico.
  • Pinedo-Rodríguez A; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, CDMX, Mexico.
  • Enriquez-Vera D; Universidad Privada San Juan Bautista, Lima, Perú.
  • Flores-Jiménez JA; Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú.
  • Ceballos-López AA; Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Mexico.
  • Rodríguez-Mejorada M; Clínica de Mérida, Mérida, México.
  • Herrera Riojas MA; Clínica de Mérida, Mérida, México.
  • Ovilla-Martínez R; Centro Hematológico HOPE, San Luis Potosí, México.
  • Báez-Islas P; Hospital Ángeles Lomas, Ciudad de México, CDMX, Mexico.
  • Cota-Rangel X; Hospital Ángeles Lomas, Ciudad de México, CDMX, Mexico.
  • Neme-Yunes Y; Hospital Ángeles Lomas, Ciudad de México, CDMX, Mexico.
  • Inclán-Alarcón S; Centro Médico ABC, Ciudad de México, CDMX, Mexico.
  • López-Flores NJ; Centro Médico ABC, Ciudad de México, CDMX, Mexico.
  • Colunga-Pedraza PR; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
  • Rodríguez-Zúñiga AC; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
  • Gómez-Almaguer D; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
Hematology ; 27(1): 249-257, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35192778
Objectives: Venetoclax combinations are a new standard for patients with acute myeloid leukemia (AML). We aimed to evaluate the safety and efficacy of these combinations in a period of accelerated approval in Latin-America.Methods: This observational study evaluated adults with acute myeloid leukemia who received venetoclax-based therapy in 11 public or private centers in Mexico and Peru for both newly diagnosed or relapsed and refractory AML.Results: Fifty patients were included; 28 with newly diagnosed (ND) AML and 22 with relapsed/refractory (RR) disease. ND patients were older (64 vs. 40 years; p < 0.001) with a lower functional capacity (ECOG ≥2 64.3% vs 9%; p < 0.001). Venetoclax was frequently combined with azacytidine (60%) and prophylactic azoles (82%) with a median maximum dose of 200 mg (range, 100-600 mg). Hematologic toxicities were common. Complete response rates including patients with incomplete hematopoietic recovery were 78.6% in ND and 45.5% in RR patients, with a median overall survival of 9.6 (95% CI 3.7-15.5) and 8 months (95% CI 4.8-11.2).Discussion: Our study showed a preferred use of venetoclax plus azacytidine over cyatrabine. Patients in the first-line setting were similar to those in the landmark studies, while most patients with relapsed disease had received prior intensive therapies. Responses were favorable, with a median survival in agreement to other reports, albeit shorter than that observed in the randomized phase-3 trials.Conclusion: Venetoclax-based therapy in AML was effective despite dose reductions and prophylactic antifungals in two middle-income countries outside of a clinical trial setting.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Leucemia Mieloide Aguda / Compostos Bicíclicos Heterocíclicos com Pontes / Antineoplásicos Tipo de estudo: Clinical_trials / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hematology Assunto da revista: HEMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Leucemia Mieloide Aguda / Compostos Bicíclicos Heterocíclicos com Pontes / Antineoplásicos Tipo de estudo: Clinical_trials / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hematology Assunto da revista: HEMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido