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Rationale and design of the Brazilian diabetes study: a prospective cohort of type 2 diabetes.
Barreto, Joaquim; Wolf, Vaneza; Bonilha, Isabella; Luchiari, Beatriz; Lima, Marcus; Oliveira, Alessandra; Vitte, Sofia; Machado, Gabriela; Cunha, Jessica; Borges, Cynthia; Munhoz, Daniel; Fernandes, Vicente; Kimura-Medorima, Sheila Tatsumi; Breder, Ikaro; Fernandez, Marta Duran; Quinaglia, Thiago; Oliveira, Rodrigo B; Chaves, Fernando; Arieta, Carlos; Guerra-Júnior, Gil; Avila, Sandra; Nadruz, Wilson; Carvalho, Luiz Sergio F; Sposito, Andrei C.
Afiliação
  • Barreto J; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Wolf V; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Bonilha I; Growth and Body Composition Lab, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, São Paulo, Brazil.
  • Luchiari B; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Lima M; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Oliveira A; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Vitte S; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Machado G; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Cunha J; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Borges C; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Munhoz D; Nephrology Division, Clinics Hospital, University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Fernandes V; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Kimura-Medorima ST; Cardiology Division, Department of Internal Medicine, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Breder I; Department of Ophthalmology, Clinics Hospital, University of Campinas, Sao Paulo, Brazil.
  • Fernandez MD; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Quinaglia T; Cardiology Division, Department of Internal Medicine, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Oliveira RB; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Chaves F; Clarity Healthcare Intelligence, Sao Paulo, Brazil.
  • Arieta C; School of Electrical and Computer Engineering, Unicamp, Sao Paulo, Brazil.
  • Guerra-Júnior G; Atherosclerosis and Vascular Biology Laboratory (Atherolab), Cardiology Division, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Avila S; Cardiology Division, Department of Internal Medicine, State University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Nadruz W; Nephrology Division, Clinics Hospital, University of Campinas (Unicamp), Sao Paulo, Brazil.
  • Carvalho LSF; Department of Ophthalmology, Clinics Hospital, University of Campinas, Sao Paulo, Brazil.
  • Sposito AC; Department of Ophthalmology, Clinics Hospital, University of Campinas, Sao Paulo, Brazil.
Curr Med Res Opin ; 38(4): 523-529, 2022 04.
Article em En | MEDLINE | ID: mdl-35174749
BACKGROUND: Optimal control of traditional risk factors only partially attenuates the exceeding cardiovascular mortality of individuals with diabetes. Employment of machine learning (ML) techniques aimed at the identification of novel features of risk prediction is a compelling target to tackle residual cardiovascular risk. The objective of this study is to identify clinical phenotypes of T2D which are more prone to developing cardiovascular disease. METHODS: The Brazilian Diabetes Study is a single-center, ongoing, prospective registry of T2D individuals. Eligible patients are 30 years old or older, with a confirmed T2D diagnosis. After an initial visit for the signature of the informed consent form and medical history registration, all volunteers undergo biochemical analysis, echocardiography, carotid ultrasound, ophthalmologist visit, dual x-ray absorptiometry, coronary artery calcium score, polyneuropathy assessment, advanced glycation end-products reader, and ambulatory blood pressure monitoring. A 5-year follow-up will be conducted by yearly phone interviews for endpoints disclosure. The primary endpoint is the difference between ML-based clinical phenotypes in the incidence of a composite of death, myocardial infarction, revascularization, and stroke. Since June/2016, 1030 patients (mean age: 57 years, diabetes duration of 9.7 years, 58% male) were enrolled in our study. The mean follow-up time was 3.7 years in October/2021. CONCLUSION: The BDS will be the first large population-based cohort dedicated to the identification of clinical phenotypes of T2D at higher risk of cardiovascular events. Data derived from this study will provide valuable information on risk estimation and prevention of cardiovascular and other diabetes-related events. CLINICALTRIALS.GOV IDENTIFIER: NCT04949152.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Infarto do Miocárdio Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Curr Med Res Opin Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Infarto do Miocárdio Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Curr Med Res Opin Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido