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Testosterone suppression impacts craniofacial growth structures during puberty : An animal study.
Reis, Caio Luiz Bitencourt; de Fátima Pereira Madureira, Magali; Cunha, Caio Luis Rocha; Junior, Wagner Costa Rossi; Araújo, Tomaz Henrique; Esteves, Alessandra; Stuani, Maria Bernadete Sasso; Kirschneck, Christian; Proff, Peter; Matsumoto, Mírian Aiko Nakane; Küchler, Erika Calvano; Silva Barroso de Oliveira, Daniela.
Afiliação
  • Reis CLB; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • de Fátima Pereira Madureira M; Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais, 37130-001, Alfenas, Brazil.
  • Cunha CLR; Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais, 37130-001, Alfenas, Brazil.
  • Junior WCR; Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais, 37130-001, Alfenas, Brazil.
  • Araújo TH; Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil.
  • Esteves A; Institute of Biomedical Sciences, Department Structural Biology, Federal University of Alfenas, Alfenas, Brazil.
  • Stuani MBS; Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil.
  • Kirschneck C; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Proff P; Department of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
  • Matsumoto MAN; Department of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany.
  • Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Silva Barroso de Oliveira D; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
J Orofac Orthop ; 84(5): 287-297, 2023 Sep.
Article em En | MEDLINE | ID: mdl-35147736
AIM: Hormones play a crucial role in growth development; however, the impact of testosterone suppression (TS) on craniofacial growth during puberty remains inconclusive. This study aimed to evaluate the impact of TS during puberty on cephalometric measurements and histological characteristics of facial growth centers. MATERIALS AND METHODS: Thirty-six heterogenic Wistar male rats were randomly allocated into experimental orchiectomy (ORX) and control (sham) groups. At an age of 23 days (prepubertal stage), orchiectomy and placebo surgery were performed. Cephalometric measurements were performed via lateral cephalograms during and after puberty. The animals were euthanized at an age of 45 days (pubertal stage) and 73 days (postpubertal stage). Histological slices of the growth centers (condyle, premaxilla, and median palatine suture) were stained with hematoxylin and eosin, and sirius red. Student's t or Mann-Whitney U tests were used to compare linear and angular cephalometric measurements across groups (α error = 5%). RESULTS: Linear and angular measurements were statistically different in ORX animals (cranial bones, maxilla, and mandible) at 45 days and 73 days. Condylar histology showed a decrease in prechondroblast differentiation and a delay of mineralization in ORX animals. Vascularization of the medium palatine suture was lower in the ORX group at 45 days. Type I and III collagen fiber synthesis was lower in the ORX groups. In the premaxillary suture, collagen fibers were better organized in the sham groups. CONCLUSIONS: Our results suggest that testosterone suppression affects craniofacial growth during puberty.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Testosterona Tipo de estudo: Clinical_trials Limite: Animals Idioma: En Revista: J Orofac Orthop Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Testosterona Tipo de estudo: Clinical_trials Limite: Animals Idioma: En Revista: J Orofac Orthop Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha