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Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state.
Barcelos Valiatti, Tiago; Silva Carvalho, Tatiane; Fernandes Santos, Fernanda; Silva Nodari, Carolina; Cayô, Rodrigo; da Silva, Juliana Thalita Paulino; da Silva, Cicileia Correia; Ferreira, Jacqueline Andrade; Moura, Lorena Brandhuber; Dos Santos, Levy Assis; Gales, Ana Cristina.
Afiliação
  • Barcelos Valiatti T; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil. tiago_valiatti@hotmail.com.
  • Silva Carvalho T; Hospital de Base Dr. Ary Pinheiro, Porto Velho, RO, Brazil.
  • Fernandes Santos F; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil.
  • Silva Nodari C; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil.
  • Cayô R; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil.
  • da Silva JTP; Laboratório de Imunologia e Bacteriologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Universidade Federal de São Paulo (UNIFESP), Diadema, SP, Brazil.
  • da Silva CC; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil.
  • Ferreira JA; Laboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho, RO, Brazil.
  • Moura LB; Laboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho, RO, Brazil.
  • Dos Santos LA; Laboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho, RO, Brazil.
  • Gales AC; Laboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho, RO, Brazil.
Braz J Microbiol ; 53(2): 795-799, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35141834
In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried blaOXA-23 and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Limite: Humans Idioma: En Revista: Braz J Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Acinetobacter / Acinetobacter baumannii Limite: Humans Idioma: En Revista: Braz J Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil