Your browser doesn't support javascript.
loading
Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos.
Rangel-Méndez, Jorge-Aarón; Rubi-Castellanos, Rodrigo; Sánchez-Cruz, Juan-Francisco; Moo-Puc, Rosa Esther.
Afiliação
  • Rangel-Méndez JA; Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional "Ignacio García Téllez", Instituto Mexicano del Seguro Social, Calle 41 No. 439, Col. Industrial, 97150 Mérida, Yucatán, México.
  • Rubi-Castellanos R; Centro de Investigaciones Regionales "Dr. Hideyo Noguchi" Calle 96 S/Nx, Av. Jacinto Canek y Calle 47, Fracc. Paseo de las Fuentes, 97225 Mérida, Yucatán, México.
  • Sánchez-Cruz JF; Coordinación de Investigación, Delegación Estatal Yucatán, Instituto Mexicano del Seguro Social, Calle 41 No. 439, Col. Industrial, 97150 Mérida, Yucatán, México.
  • Moo-Puc RE; Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional "Ignacio García Téllez", Instituto Mexicano del Seguro Social, Calle 41 No. 439, Col. Industrial, 97150 Mérida, Yucatán, México.
Transl Cancer Res ; 8(1): 23-34, 2019 Feb.
Article em En | MEDLINE | ID: mdl-35116730
BACKGROUND: Tamoxifen metabolism is translated into four genetic phenotypes (GP): genetic poor metabolizer (gPM); genetic intermediate metabolizer (gIM); genetic normal metabolizer (gNM); and genetic ultra-rapid metabolizer (gUM). Although CYP2D6 is involved in tamoxifen biotransformation, its association with tamoxifen side effects (TSE) is limited. Therefore, we evaluated CYP2D6 GP and clinical variables as potential predictors of TSE in Mexican Mestizo patients. METHODS: This cross-sectional study evaluated CYP2D6 GP, clinical data, and self-reported TSE in 71 women. Potential predictors were tested in uni- and multivariable models. RESULTS: Hot flashes (57.75%), arthralgia (45.07%), headache (43.66%), and cramps (39.44%) were the most frequent TSE. Three GP were identified: gPM (2.8%); gNM (93.0%); and gUM (4.2%). In the univariate analysis, none of the GP was predictive of TSE. However, the uni- and multivariable models showed contraceptive use and chemotherapy treatment prior to tamoxifen therapy to be predictive. Two alleles were identified for the first time at unusually high frequencies: CYP2D6*34 (13.2%); and *39 (14.7%). CONCLUSIONS: Our findings indicate that CYP2D6 GP were not significantly predictive of TSE, though two clinical descriptors were. The present results are a valuable contribution to pharmacogenetic characterization of Mexican Mestizo populations who, like other Latin-American groups, are poorly represented in the literature.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Transl Cancer Res Ano de publicação: 2019 Tipo de documento: Article País de publicação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Transl Cancer Res Ano de publicação: 2019 Tipo de documento: Article País de publicação: China