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CXCL12/CXCR4 axis gene variants contribute to an increased vulnerability to HPV infection and cervical oncogenesis.
Okuyama, Nádia Calvo Martins; Cezar-Dos-Santos, Fernando; Trugilo, Kleber Paiva; Esposito, Aline; Guembarovski, Roberta Losi; Couto-Filho, José d'Oliveira; Watanabe, Maria Angelica Ehara; de Oliveira, Karen Brajão.
Afiliação
  • Okuyama NCM; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil.
  • Cezar-Dos-Santos F; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil.
  • Trugilo KP; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil.
  • Esposito A; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil.
  • Guembarovski RL; Laboratory of Mutagenesis and Oncogenetics, Department of Biological Sciences, Londrina State University, Londrina, PR, Brazil.
  • Couto-Filho JD; Cancer Hospital of Londrina, Londrina, PR, Brazil.
  • Watanabe MAE; Laboratory of Study and Application of DNA Polymorphism, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil.
  • de Oliveira KB; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, PR, Brazil. karen.brajao@uel.br.
J Cancer Res Clin Oncol ; 148(4): 793-802, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35083551
PURPOSE: Every year, more than half a million women are diagnosed with cervical cancer (CC). Individual factors may contribute to the cervical cancer development, such as immunogenetic variation. CXCL12/CXCR4 axis is involved in tumor progression and aggressiveness. In the present study, we aimed to investigate a possible association between two single-nucleotide variants (CXCL12 rs1801157 and CXCR4 rs2228014) with HPV infection and cervical cancer development. METHODS: PCR technique was used to test HPV positivity in 424 women, in which the allelic frequency of CXCL12 rs1801157 and CXCR4 rs2228014 was also assessed by PCR-restriction fragment length polymorphism. RESULTS: CXCL12 rs1801157 was associated with HPV infection in the allelic distribution as well in the codominant, dominant and recessive genetic models; as well with squamous intraepithelial lesions (SIL) and CC in the codominant and dominant models. CXCR4 rs2228014 was associated to HPV infection in the codominant model and allelic distribution; as well with SIL/CC in the codominant, dominant and allelic models. Independent associations were found for CXCL12 AA genotype and HPV infection, SIL and CC development, as well as, CXCR4 allele T and HPV infection and CC. The variants interaction analysis demonstrated that the presence of both polymorphisms increases the susceptibility of HPV infection in 10.1 times, SIL (2 times) and CC development in 4.2 times. CONCLUSIONS: This is the first study demonstrating that the interaction of CXCL12 and CXCR4 variants contributes to the increased susceptibility of HPV infection, squamous intraepithelial lesions and cervical cancer development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Cancer Res Clin Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Cancer Res Clin Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha